Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong
genetic basis. Yet, only a small fraction of potentially causal genes—about 65 genes out of an …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus, …

We present SEEK (search-based exploration of expression compendia; http://seek.princeton.edu/
), a query-based search engine for very large transcriptomic data collections, including …

A major obstacle to treating Alzheimer's disease (AD) is our lack of understanding of the
molecular mechanisms underlying selective neuronal vulnerability, a key characteristic of the …

Precise discrimination of tumor from normal tissues remains a major roadblock for therapeutic
efficacy of chimeric antigen receptor (CAR) T cells. Here, we perform a comprehensive in …

Congenital abnormalities of the kidney and urinary tract are among the most common birth
defects, affecting 3% of newborns. The human kidney forms around a million nephrons from a …

IMP (Integrative Multi-species Prediction), originally released in 2012, is an interactive web
server that enables molecular biologists to interpret experimental results and to generate …

Many functionally important interactions between genes and proteins involved in
immunological diseases and processes are unknown. The exponential growth in public high-…

Protein–protein interactions (PPIs) drive cellular processes and responses to environmental
cues, reflecting the cellular state. Here we develop Tapioca, an ensemble machine learning …

Resolving chromatin-remodeling-linked gene expression changes at cell-type resolution is
important for understanding disease states. Here we describe MAGICAL (Multiome …