User profiles for Alina Iuga
 | Alina IugaUniversity of North Carolina at Chapel Hill Verified email at unchealth.unc.edu Cited by 3719 |
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Ferroptosis is a form of cell death that results from the catastrophic accumulation of lipid
reactive oxygen species (ROS). Oncogenic signaling elevates lipid ROS production in many …
reactive oxygen species (ROS). Oncogenic signaling elevates lipid ROS production in many …
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Precise regulation of the NFAT (nuclear factor of activated T cells) family of transcription factors
(NFAT1–4) is essential for vertebrate development and function 1 . In resting cells, NFAT …
(NFAT1–4) is essential for vertebrate development and function 1 . In resting cells, NFAT …
[HTML][HTML] Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data
The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes
pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers …
pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers …
[PDF][PDF] β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer
Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling
in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines …
in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines …
A functional genomics predictive network model identifies regulators of inflammatory bowel disease
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …
sets to construct predictive models of IBD. We present a predictive model of the immune …
Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma
Perineural invasion (PNI) is one of the established prognostic factors in pancreatic ductal
adenocarcinoma (PDAC). However, the prognostic significance of PNI in patients with PDAC …
adenocarcinoma (PDAC). However, the prognostic significance of PNI in patients with PDAC …
Cholinergic signaling via muscarinic receptors directly and indirectly suppresses pancreatic tumorigenesis and cancer stemness
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been
shown to modulate tumor growth. However, whether cholinergic signaling directly regulates …
shown to modulate tumor growth. However, whether cholinergic signaling directly regulates …
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes
Objective Pancreatic ductal adenocarcinoma (PDA) has among the highest stromal
fractions of any cancer and this has complicated attempts at expression-based molecular …
fractions of any cancer and this has complicated attempts at expression-based molecular …
Lysosomal acid lipase deficiency allograft recurrence and liver failure-clinical outcomes of 18 liver transplantation patients
… Alina Iuga and Helen Remotti provided pathology images and analyses. Steven Lobritto,
Marie Isabel Fiel, Thomas Schiano and Manisha Balwani provided clinical and pathology data, …
Marie Isabel Fiel, Thomas Schiano and Manisha Balwani provided clinical and pathology data, …
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of
T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
T cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …