Background Transplantation is an effective treatment for end‐stage lung disease, but the
donor organ shortage is a major problem. Ex‐vivo lung perfusion (EVLP) of extended criteria …

Transplantation is an effective treatment for end-stage lung disease but donor organ shortage
is a major problem. Ex-vivo lung perfusion (EVLP) of marginal organs enables functional …

Presenting cells with a two -dimensional (2D) substrate, as is the case with traditional cell
culture, causes them to aberrantly flatten out, and lose their characteristic cell shape. With the …

The Dominantly Inherited Alzheimer Network (DIAN) is an international collaboration studying
autosomal dominant Alzheimer disease (ADAD). ADAD arises from mutations occurring in …

INTRODUCTION Studies suggest distinct differences in the development, presentation,
progression, and response to treatment of Alzheimer's disease (AD) between females and males…

Background In people with genetic forms of Alzheimer's disease, such as in Down syndrome
and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's …

Background Neuroimaging studies often quantify tau burden in standardized brain regions
to assess Alzheimer disease (AD) progression. However, this method ignores another key …

Objective: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in
a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (…

Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …

Background: It remains unknown whether associations between protective lifestyles and the
risk of sporadic dementia in observational studies also affect age at symptom onset (AAO) in …