[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, NG Martin, GW Montgomery, AD Murray… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

…, S Männistö, B Müller-Myhsok, AD Murray… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Neural mechanisms of imitation and 'mirror neuron'functioning in autistic spectrum disorder

…, GD Waiter, A Gilchrist, DI Perrett, AD Murray… - Neuropsychologia, 2006 - Elsevier
An association between autistic spectrum disorder and imitative impairment might result from
dysfunction in mirror neurons (MNs) that serve to relate observed actions to motor codings. …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

…, NG Martin, C Matalliotaki, M Matalliotakis, AD Murray… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

[HTML][HTML] Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N= 112 117)

…, LS Hall, S Padmanabhan, AD Murray… - Molecular …, 2017 - nature.com
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …

An overview of prevalence, determinants and health outcomes of polypharmacy

M Khezrian, CJ McNeil, AD Murray… - … advances in drug …, 2020 - journals.sagepub.com
A high rate of polypharmacy is, in part, a consequence of the increasing proportion of
multimorbidity in the ageing population worldwide. Our understanding of the potential harm of …

What provides cerebral reserve?

RT Staff, AD Murray, IJ Deary, LJ Whalley - Brain, 2004 - academic.oup.com
The cerebral reserve hypothesis is a heuristic concept used to explain apparent protection
from the onset of cerebral disease and/or cognitive decline in old age. A significant obstacle …

[HTML][HTML] Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's disease

…, DJ Wischik, P Bentham, AD Murray… - Journal of …, 2015 - content.iospress.com
Background: As tau aggregation pathology correlates with clinical dementia in Alzheimer’s
disease (AD), a tau aggregation inhibitor (TAI) could have therapeutic utility. …

A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder

GD Waiter, JHG Williams, AD Murray, A Gilchrist… - Neuroimage, 2004 - Elsevier
Autistic spectrum disorder (ASD) has been associated with abnormal neuroanatomy in
many imaging and neuropathological studies. Both global brain volume differences and …

Brain White Matter Hyperintensities: Relative Importance of Vascular Risk Factors in Nondemented Elderly People1

AD Murray, RT Staff, SD Shenkin, IJ Deary, JM Starr… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively determine whether there is an association between brain white
matter signal hyperintensities on magnetic resonance (MR) images and potential risk …