A major question in evolutionary biology is how natural selection has shaped patterns of
genetic variation across the human genome. Previous work has documented a reduction in …

Both genetic drift and natural selection cause the frequencies of alleles in a population to vary
over time. Discriminating between these two evolutionary forces, based on a time series of …

High-throughput pooled resequencing offers significant potential for whole genome population
sequencing. However, its main drawback is the loss of haplotype information. In order to …

Spatial properties of tumour growth have profound implications for cancer progression,
therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division …

10.7554/eLife.10670.001 In the early days of HIV treatment, drug resistance occurred rapidly
and predictably in all patients, but under modern treatments, resistance arises slowly, if at …

It is increasingly appreciated that pathogens can spread as infectious units constituted by
multiple, genetically diverse genomes, also called collective infectious units or genome …

Drug resistance is a costly consequence of pathogen evolution and a major concern in public
health. In this review, we show how population genetics can be used to study the evolution …

Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These
therapies should prevent HIV drug resistance evolution, because one or more drugs suppress …

In the long-term neutral equilibrium, high rates of migration between subpopulations result
in little population differentiation. However, in the short-term, even very abundant migration …

HIV can evolve remarkably quickly in response to antiretroviral therapies and the immune
system. This evolution stymies treatment effectiveness and prevents the development of an …