Sleep apnea is highly prevalent in patients with cardiovascular disease. These disordered
breathing events are associated with a profile of perturbations that include intermittent hypoxia…

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic
intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are …

… Williams, initiated studies to elucidate the relationship of rest beAmita Sehgal, and Allan I.
Pack … Hendricks, JC, Sehgal, A., and Pack, AI (2000). The need for a simple animal model to …

There are fundamental similarities between sleep in mammals and quiescence in the arthropod
Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient 1 , …

One‐seventh of the world's adult population, or approximately one billion people, are estimated
to have OSA. Over the past four decades, obesity, the main risk factor for OSA, has risen …

To determine whether a cumulative sleep debt (in a range commonly experienced) would
result in cumulative changes in measures of waking neurobehavioral alertness, 16 healthy …

Obstruction of the upper airway during sleep (OSAS) is widely treated by having patients self-administer
nasal continuous positive airway pressure (CPAP). To obtain objective evidence …

We used sophisticated volumetric analysis techniques with magnetic resonance imaging in
a case–control design to study the upper airway soft tissue structures in 48 control subjects (…

The geometry and caliber of the upper airway in apneic patients differs from those in normal
subjects. The apneic airway is smaller and is narrowed laterally. Examination of the soft …

Study Objectives: Evidence suggests that, to maintain treatment effects, nasal continuous
positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) needs to be used …