… the 6-month assessment (p=0·022; table 2). We noted significant reduction in opioid use
from baseline to 3 months (p=0·021) and baseline to 6 months (p=0·011) post-SBRT (table 2). …

Recent far-reaching advances in synthetic biology have yielded exciting tools for the
creation of new materials. Conversely, advances in the fundamental understanding of soft-…

Compartmentalization of biomolecules within lipid membranes is a fundamental requirement
of living systems and an essential feature of many pharmaceutical therapies. However, …

The ability of cells to mount localized responses to external or internal stimuli is critically
dependent on organization of lipids and proteins in the plasma membrane. Involvement of the …

Clathrin-mediated endocytosis (CME) is the major pathway for concentrative uptake of receptors
and receptor–ligand complexes (cargo). Although constitutively internalized cargos are …

Dynamic interplay between the plasma membrane and underlying cytoskeleton is essential
for cellular shape change. Spatial organization of actin filaments, the growth of which …

We are much better at taking cells apart than putting them together. Reconstitution of
biological processes from component molecules has been a powerful but difficult approach to …

Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by
closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion). …

Directed evolution has long been a key strategy to generate enzymes with desired properties
like high selectivity, but experimental barriers and analytical costs of screening enormous …

Micropipette aspiration measures the mechanical properties of single cells. A traditional
micropipette aspiration system requires a bulky infrastructure and has a low throughput and …