The complicated role of nuclear factor erythroid-derived 2-like 2 in allergy and asthma

CE Rockwell, Y Jin, AP Boss, LM Kaiser… - Drug Metabolism and …, 2022 - ASPET
Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a stress-activated transcription factor that is
highly responsive to oxidative stress and electrophilic stimuli. Upon activation, Nrf2 …

[PDF][PDF] Acute inhibition of heterotrimeric kinesin-2 function reveals mechanisms of intraflagellar transport in mammalian cilia

MF Engelke, B Waas, SE Kearns, A Suber, A Boss… - Current Biology, 2019 - cell.com
The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by
kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric KIF3A/…

[PDF][PDF] Protein interaction analysis provides a map of the spatial and temporal organization of the ciliary gating zone

D Takao, L Wang, A Boss, KJ Verhey - Current Biology, 2017 - cell.com
The motility and signaling functions of the primary cilium require a unique protein and lipid
composition that is determined by gating mechanisms localized at the base of the cilium. …

The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells

AP Boss, RA Freeborn, DM Duriancik… - Food and chemical …, 2018 - Elsevier
Tert-butylhydroquinone (tBHQ) is a commonly used food preservative with known
immunomodulatory activity; however, there is little information regarding its role on natural killer (NK) …

Trivalent arsenic impairs the effector response of human CD4+ and CD8+ T cells to influenza A virus ex vivo

RA Freeborn, AP Boss, LM Kaiser, EM Gardner… - Food and Chemical …, 2022 - Elsevier
Arsenic is a persistent environmental contaminant that humans are exposed to primarily
through contaminated water supplies. Arsenic has been shown to have numerous …

The protective effect of butylated hydroxytoluene and 3-hydroxytyrosol on food allergy in mice

Y Jin, KE Guzmán, AP Boss, V Gangur… - Immunopharmacology …, 2023 - Taylor & Francis
Objective To test the effect of two dietary antioxidants: butylated hydroxytoluene (BHT) and 3-hydroxytyrosol
(3-HT) in experimental food allergy. Methods BALB/c mice maintained on …

Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro

LM Kaiser, RA Freeborn, AP Boss, Y Jin, CE Rockwell - Toxicology in Vitro, 2024 - Elsevier
Arsenic compounds are common environmental toxicants worldwide and particularly
enriched in the Northeast and the Southwestern United States, the Alps, and Bangladesh. …

Interleukin-6 drives key pathologic outcomes in experimental acetaminophen-induced liver failure

…, TC Yen, R Freeborn, R Kennedy, B Bhushan, A Boss… - BioRxiv, 2021 - biorxiv.org
Background and Aims In severe cases of acetaminophen (APAP) overdose, acute liver
injury rapidly progresses to acute liver failure (ALF), producing life-threatening complications …

AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML

EC Sayitoglu, BA Luca, AP Boss, BC Thomas… - bioRxiv, 2023 - biorxiv.org
T cells are important for the control of acute myeloid leukemia (AML), a common and often
deadly malignancy. We observed that some AML patient samples are resistant to killing by …

The role of the stress‐activated transcription factor Nrf2 in OVA‐induced food allergy

Y Jin, A Boss, J Bursley, V Gangur… - The FASEB …, 2021 - Wiley Online Library
Immune‐mediated adverse reactions to food allergens are rising at a striking rate, but the
underlying cause is unknown. The purpose of the present studies was to determine the effect …