User profiles for Allison M. Bosworth

Allison Bosworth

University of Southern California
Verified email at usc.edu
Cited by 146

[PDF][PDF] iPSC-derived brain endothelium exhibits stable, long-term barrier function in perfused hydrogel scaffolds

SL Faley, EH Neal, JX Wang, AM Bosworth, CM Weber… - Stem Cell Reports, 2019 - cell.com
There is a profound need for functional, biomimetic in vitro tissue constructs of the human
blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeutic …

Development of an N-cadherin biofunctionalized hydrogel to support the formation of synaptically connected neural networks

BJ O'Grady, KM Balotin, AM Bosworth… - ACS biomaterials …, 2020 - ACS Publications
In vitro models of the human central nervous system (CNS), particularly those derived from
induced pluripotent stem cells (iPSCs), are becoming increasingly recognized as useful …

[HTML][HTML] Modeling neurovascular disorders and therapeutic outcomes with human-induced pluripotent stem cells

AM Bosworth, SL Faley, LM Bellan… - … in Bioengineering and …, 2018 - frontiersin.org
The neurovascular unit (NVU) is composed of neurons, astrocytes, pericytes, and endothelial
cells that form the blood–brain barrier (BBB). The NVU regulates material exchange …

Influence of Substrate Stiffness on Barrier Function in an iPSC-Derived In Vitro Blood-Brain Barrier Model

AM Bosworth, H Kim, KP O'Grady, I Richter… - Cellular and Molecular …, 2022 - Springer
Introduction Vascular endothelial cells respond to a variety of biophysical cues such as
shear stress and substrate stiffness. In peripheral vasculature, extracellular matrix (ECM) …

Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.

…, A Nackenoff, W Romero-Fernandez, AM Bosworth… - bioRxiv, 2024 - biorxiv.org
Cerebral amyloid angiopathy (CAA) is a vasculopathy characterized by vascular β-amyloid (Aβ)
deposition on cerebral blood vessels. CAA is closely linked to Alzheimer′s disease (AD…

[PDF][PDF] Perfusion Stabilizes Long-Term Barrier Function of iPSC-derived Brain Endothelial Cells in 3D Hydrogel Channels

SL Faley, EK Hollmann, JX Wang, AM Bosworth… - abstracts.biomaterials.org
Conclusions In this study, we show that iPSC-derived BMECs form confluent monolayer in
gelatin hydrogel channels with robust barrier properties. Perfusion under low-shear …

Three‐dimensional study on morphological changes of arterioles in Cerebral Amyloid Angiopathy

LV Antunes, AM Bosworth, A Nackenoff… - Alzheimer's & …, 2022 - Wiley Online Library
Background The accumulation of β‐amyloid plaques in the brain is a hallmark of Alzheimer’s
disease. Vascular involvement is also common in the form of cerebral amyloid angiopathy (…

Neighborhood environment and physical activity among older women: Findings from the San Diego Cohort of the Women's Health Initiative

…, C Morgan, RD Langer, M Allison - … of physical activity …, 2014 - journals.humankinetics.com
… Kerr (jkerr@ucsd.edu), Norman, Millstein, Adams, Morgan, and Allison are with the Dept of
Family … Li F, Fisher KJ, Brownson RC, Bosworth M. Multilevel modelling of built environment …

Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis

…, DS Siscovick, B Kestenbaum, M Allison… - The Journal of …, 2015 - academic.oup.com
Context: Aldosterone and PTH are implicated in the pathogenesis of cardiovascular and
skeletal diseases. An expanding body of evidence supports a bidirectional and positive …

Fibroblast growth factor 23, mineral metabolism, and adiposity in normal kidney function

S Zaheer, IH De Boer, M Allison… - The Journal of …, 2017 - academic.oup.com
… Given that chronic kidney disease is a strong predictor of FGF23, we excluded participants
with an eGFR <60 mL/min/1.73m 2 to reduce confounding. After exclusions, the final sample …