User profiles for Allison M. Bosworth
Allison BosworthUniversity of Southern California Verified email at usc.edu Cited by 146 |
[PDF][PDF] iPSC-derived brain endothelium exhibits stable, long-term barrier function in perfused hydrogel scaffolds
There is a profound need for functional, biomimetic in vitro tissue constructs of the human
blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeutic …
blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeutic …
Development of an N-cadherin biofunctionalized hydrogel to support the formation of synaptically connected neural networks
BJ O'Grady, KM Balotin, AM Bosworth… - ACS biomaterials …, 2020 - ACS Publications
In vitro models of the human central nervous system (CNS), particularly those derived from
induced pluripotent stem cells (iPSCs), are becoming increasingly recognized as useful …
induced pluripotent stem cells (iPSCs), are becoming increasingly recognized as useful …
[HTML][HTML] Modeling neurovascular disorders and therapeutic outcomes with human-induced pluripotent stem cells
The neurovascular unit (NVU) is composed of neurons, astrocytes, pericytes, and endothelial
cells that form the blood–brain barrier (BBB). The NVU regulates material exchange …
cells that form the blood–brain barrier (BBB). The NVU regulates material exchange …
Influence of Substrate Stiffness on Barrier Function in an iPSC-Derived In Vitro Blood-Brain Barrier Model
Introduction Vascular endothelial cells respond to a variety of biophysical cues such as
shear stress and substrate stiffness. In peripheral vasculature, extracellular matrix (ECM) …
shear stress and substrate stiffness. In peripheral vasculature, extracellular matrix (ECM) …
Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.
…, A Nackenoff, W Romero-Fernandez, AM Bosworth… - bioRxiv, 2024 - biorxiv.org
Cerebral amyloid angiopathy (CAA) is a vasculopathy characterized by vascular β-amyloid (Aβ)
deposition on cerebral blood vessels. CAA is closely linked to Alzheimer′s disease (AD…
deposition on cerebral blood vessels. CAA is closely linked to Alzheimer′s disease (AD…
[PDF][PDF] Perfusion Stabilizes Long-Term Barrier Function of iPSC-derived Brain Endothelial Cells in 3D Hydrogel Channels
SL Faley, EK Hollmann, JX Wang, AM Bosworth… - abstracts.biomaterials.org
Conclusions In this study, we show that iPSC-derived BMECs form confluent monolayer in
gelatin hydrogel channels with robust barrier properties. Perfusion under low-shear …
gelatin hydrogel channels with robust barrier properties. Perfusion under low-shear …
Three‐dimensional study on morphological changes of arterioles in Cerebral Amyloid Angiopathy
LV Antunes, AM Bosworth, A Nackenoff… - Alzheimer's & …, 2022 - Wiley Online Library
Background The accumulation of β‐amyloid plaques in the brain is a hallmark of Alzheimer’s
disease. Vascular involvement is also common in the form of cerebral amyloid angiopathy (…
disease. Vascular involvement is also common in the form of cerebral amyloid angiopathy (…
Neighborhood environment and physical activity among older women: Findings from the San Diego Cohort of the Women's Health Initiative
…, C Morgan, RD Langer, M Allison - … of physical activity …, 2014 - journals.humankinetics.com
… Kerr (jkerr@ucsd.edu), Norman, Millstein, Adams, Morgan, and Allison are with the Dept of
Family … Li F, Fisher KJ, Brownson RC, Bosworth M. Multilevel modelling of built environment …
Family … Li F, Fisher KJ, Brownson RC, Bosworth M. Multilevel modelling of built environment …
Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis
…, DS Siscovick, B Kestenbaum, M Allison… - The Journal of …, 2015 - academic.oup.com
Context: Aldosterone and PTH are implicated in the pathogenesis of cardiovascular and
skeletal diseases. An expanding body of evidence supports a bidirectional and positive …
skeletal diseases. An expanding body of evidence supports a bidirectional and positive …
Fibroblast growth factor 23, mineral metabolism, and adiposity in normal kidney function
S Zaheer, IH De Boer, M Allison… - The Journal of …, 2017 - academic.oup.com
… Given that chronic kidney disease is a strong predictor of FGF23, we excluded participants
with an eGFR <60 mL/min/1.73m 2 to reduce confounding. After exclusions, the final sample …
with an eGFR <60 mL/min/1.73m 2 to reduce confounding. After exclusions, the final sample …