Mammalian pregnancy involves tremendous de novo maternal vascular construction to
adequately support conceptus development. In early mouse decidua basalis (DB), maternal …

The role of sex hormones in regulating immune responses in the female genital tract has
been recognized for decades. More recently, it has become increasingly clear that sex …

The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased
risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. …

Mice ablated for the gene encoding the transcription factor Nfil3 lack peripheral natural killer
(NK) cells but retain tissue-resident NK cells, particularly in mucosal sites, including virgin …

The progestin-based hormonal contraceptive Depot Medroxyprogesterone Acetate (DMPA)
is widely used in sub-Saharan Africa, where HIV-1 is endemic. Meta-analyses have shown …

Herpes simplex virus type 2 (HSV-2) infection affects 24 million births annually and is
associated with adverse pregnancy outcomes, including neonatal herpes; however, the …

The decidua basalis of developing mouse implantation sites is highly enriched in CD45 +
leukocytes. In intact, syngeneically mated C57BL/6 decidua basalis examined at gestation day …

Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT)
genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age …

Genetic knockdown (KD) of the mouse Ly49 receptor family is reported to result in infertility
despite the presence of zona-enclosed blastocysts in the uterus. Ly49 receptors regulate …

Chapter Summary Whole mount in situ immunohistochemistry is a simple technique that
can be customized very easily to the investigator’s interests. It permits acquisition of …