Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and …

AS Vanecek, J Mojsilovic-Petrovic… - ACS Chemical …, 2023 - ACS Publications
A hexanucleotide repeat expansion (HRE) in an intron of gene C9ORF72 is the most common
cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. The HRE …

Synthesis, structure, properties, and cytotoxicity of a (quinoline) RuCp+ complex

Z Hou, AS Vanecek, JJ Tepe, AL Odom - Dalton Transactions, 2023 - pubs.rsc.org
A rare example of a structurally characterized metal quinoline complex was prepared using
a non-covalent quinoline-based proteasome inhibitor (Quin1), and a related complex …

[HTML][HTML] Small molecule 20S proteasome enhancer regulates MYC protein stability and exhibits antitumor activity in multiple myeloma

E Njomen, A Vanecek, TA Lansdell, YT Yang… - Biomedicines, 2022 - mdpi.com
Despite the addition of several new agents to the armamentarium for the treatment of
multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and …

Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy

E Njomen, TA Lansdell, A Vanecek, V Benham… - bioRxiv, 2020 - biorxiv.org
Enhancing proteasome activity is a potential new therapeutic strategy to prevent the accumulation
of aberrant high levels of protein that drive the pathogenesis of many diseases. Herein…

[BOOK][B] Synthesis of Lactic Acid and 3-Hydroxypropionic Acid Via 1, 3-and 1, 4-Hydration of Acetylenecarboxylic Acid

KL Kwiatkowski - 2023 - search.proquest.com
Fossil fuel use remains prevalent for the production of chemicals, but with increasing
environmental concern and limited availability, alternative sustainable methods are being …

Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.

J Vanecek, DC Klein - Endocrinology, 1992 - academic.oup.com
… However, we were unsuccessful (Vanecek, J., and DC Klein, unpublished results), suggesting
that CAMP may not be … (Allison Park, PA) and kept in our facilities on an automatically …

See‐Saw Signal Processing in Pinealocytes Involves Reciprocal Changes in the α1‐Adrenergic Component of the Cyclic GMP Response and the β‐Adrenergic …

J Vanecek, D Sugden, JL Weller… - Journal of …, 1986 - Wiley Online Library
… curves for NE, isoproterenol (ISO), phenylephrine (PE), and the combination of IS0 and PE
in LD pinealocytes in this study were essentially identical to published data (Vanecek et al., …

A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin

J Vanecek, DC Klein - Endocrinology, 1993 - academic.oup.com
… rats (Zivic-Miller Laboratories, Allison Park, PA) were kept in our facilities in an automatically
Vanecek J, Klein DC 1992 Melatonin inhibits gonadotrophinreleasing hormone-induced …

Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells

J Vanecek, DC Klein - Endocrinology, 1992 - academic.oup.com
… rats (Zivic-Miller Laboratories, Allison Park, PA) were kept in our facilities in an automaticallv
… cells in a series of experiments (Vanecek, J., and DC Klein, unpublished observations). …

Nickel

W Kurtz, H Vanecek - W Tungsten: Metal, Chemical Reactions with Metals …, 1987 - Springer
23 Nickel Page 1 23 Nickel 23.1 Bulk Reactions 23.1.1 Phase Diagram 147 The W-Ni
systemwas reviewed in "Nickel" B 1,1965, pp. 255/69, "Hansen" (1958), pp. 1057/9, "Elliott" (1965)…