Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and …
AS Vanecek, J Mojsilovic-Petrovic… - ACS Chemical …, 2023 - ACS Publications
A hexanucleotide repeat expansion (HRE) in an intron of gene C9ORF72 is the most common
cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. The HRE …
cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. The HRE …
Synthesis, structure, properties, and cytotoxicity of a (quinoline) RuCp+ complex
A rare example of a structurally characterized metal quinoline complex was prepared using
a non-covalent quinoline-based proteasome inhibitor (Quin1), and a related complex …
a non-covalent quinoline-based proteasome inhibitor (Quin1), and a related complex …
[HTML][HTML] Small molecule 20S proteasome enhancer regulates MYC protein stability and exhibits antitumor activity in multiple myeloma
Despite the addition of several new agents to the armamentarium for the treatment of
multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and …
multiple myeloma (MM) in the last decade and improvements in outcomes, the refractory and …
Enhancing c-MYC degradation via 20S proteasome activation induces in vivo anti-tumor efficacy
E Njomen, TA Lansdell, A Vanecek, V Benham… - bioRxiv, 2020 - biorxiv.org
Enhancing proteasome activity is a potential new therapeutic strategy to prevent the accumulation
of aberrant high levels of protein that drive the pathogenesis of many diseases. Herein…
of aberrant high levels of protein that drive the pathogenesis of many diseases. Herein…
[BOOK][B] Synthesis of Lactic Acid and 3-Hydroxypropionic Acid Via 1, 3-and 1, 4-Hydration of Acetylenecarboxylic Acid
KL Kwiatkowski - 2023 - search.proquest.com
Fossil fuel use remains prevalent for the production of chemicals, but with increasing
environmental concern and limited availability, alternative sustainable methods are being …
environmental concern and limited availability, alternative sustainable methods are being …
Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.
J Vanecek, DC Klein - Endocrinology, 1992 - academic.oup.com
… However, we were unsuccessful (Vanecek, J., and DC Klein, unpublished results), suggesting
that CAMP may not be … (Allison Park, PA) and kept in our facilities on an automatically …
that CAMP may not be … (Allison Park, PA) and kept in our facilities on an automatically …
See‐Saw Signal Processing in Pinealocytes Involves Reciprocal Changes in the α1‐Adrenergic Component of the Cyclic GMP Response and the β‐Adrenergic …
J Vanecek, D Sugden, JL Weller… - Journal of …, 1986 - Wiley Online Library
… curves for NE, isoproterenol (ISO), phenylephrine (PE), and the combination of IS0 and PE
in LD pinealocytes in this study were essentially identical to published data (Vanecek et al., …
in LD pinealocytes in this study were essentially identical to published data (Vanecek et al., …
A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin
J Vanecek, DC Klein - Endocrinology, 1993 - academic.oup.com
… rats (Zivic-Miller Laboratories, Allison Park, PA) were kept in our facilities in an automatically
… Vanecek J, Klein DC 1992 Melatonin inhibits gonadotrophinreleasing hormone-induced …
… Vanecek J, Klein DC 1992 Melatonin inhibits gonadotrophinreleasing hormone-induced …
Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells
J Vanecek, DC Klein - Endocrinology, 1992 - academic.oup.com
… rats (Zivic-Miller Laboratories, Allison Park, PA) were kept in our facilities in an automaticallv
… cells in a series of experiments (Vanecek, J., and DC Klein, unpublished observations). …
… cells in a series of experiments (Vanecek, J., and DC Klein, unpublished observations). …
Nickel
W Kurtz, H Vanecek - W Tungsten: Metal, Chemical Reactions with Metals …, 1987 - Springer
23 Nickel Page 1 23 Nickel 23.1 Bulk Reactions 23.1.1 Phase Diagram 147 The W-Ni
systemwas reviewed in "Nickel" B 1,1965, pp. 255/69, "Hansen" (1958), pp. 1057/9, "Elliott" (1965)…
systemwas reviewed in "Nickel" B 1,1965, pp. 255/69, "Hansen" (1958), pp. 1057/9, "Elliott" (1965)…