DNA methylation regulates gene transcription and has been suggested to encode
psychopathologies derived from early life stress. We found that methylation regulated the expression …

10.7554/eLife.00759.001 Social behavior in mammals is often studied in pairs under artificial
conditions, yet groups may rely on more complicated social structures. Here, we use a …

The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and
possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity …

The link between dysregulated serotonergic activity and depression and anxiety disorders
is well established, yet the molecular mechanisms underlying these psychopathologies are …

N 6 -methyladenosine (m 6 A) and N 6 ,2′-O-dimethyladenosine (m 6 Am) are abundant
mRNA modifications that regulate transcript processing and translation. The role of both, here …

Recent studies have revealed that patients with psychiatric disorders have altered microRNA
(miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have …

Chronic stress is a trigger for several psychiatric disorders, including depression; however,
critical individual differences in resilience to both the behavioral and the neurochemical …

The etiology and pathophysiology of anxiety and mood disorders is linked to inappropriate
regulation of the central stress response. To determine whether microRNAs have a functional …

Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been
implicated in stress-related psychopathologies such as depression and anxiety. It has been …