[HTML][HTML] Apoptotic stress causes mtDNA release during senescence and drives the SASP
Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP) 1 . Mitochondria are major …
chronic senescence-associated secretory phenotype (SASP) 1 . Mitochondria are major …
Manipulating mitochondrial electron flow enhances tumor immunogenicity
Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative
contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow…
contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow…
Mitochondrial DNA: cellular genotoxic stress sentinel
High copy number, damage prone, and lean on repair mechanisms are unique features of
mitochondrial DNA (mtDNA) that are hard to reconcile with its essentiality for oxidative …
mitochondrial DNA (mtDNA) that are hard to reconcile with its essentiality for oxidative …
Mitochondrial DNA stress signalling protects the nuclear genome
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …
mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins …
PIM kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species
Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and
it is highly correlated with metastasis, therapeutic resistance, and disease recurrence in …
it is highly correlated with metastasis, therapeutic resistance, and disease recurrence in …
Hypoxia-inducible PIM kinase expression promotes resistance to antiangiogenic agents
Purpose: Patients develop resistance to antiangiogenic drugs, secondary to changes in the
tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their …
tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases and their …
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions
…, GS Shadel, AG Moyzis, AG Sainz… - … of Physiology-Lung …, 2022 - journals.physiology.org
Increased plasma mitochondrial DNA concentrations are associated with poor outcomes in
multiple critical illnesses, including COVID-19. However, current methods of cell-free …
multiple critical illnesses, including COVID-19. However, current methods of cell-free …
Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors
AL Casillas, SS Chauhan, RK Toth, AG Sainz… - Oncogene, 2021 - nature.com
Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor
1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is …
1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is …
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP
In the version of this article initially published, US NIH grants R33AG61456-4 and
R01AG064165 were missing from the Acknowledgements section and have now been …
R01AG064165 were missing from the Acknowledgements section and have now been …
[HTML][HTML] The Pathophysiology of COVID-19 and SARS-CoV-2 Infection: Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 …
…, GS Shadel, AG Moyzis, AG Sainz… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Increased plasma mitochondrial DNA concentrations are associated with poor outcomes in
multiple critical illnesses, including COVID-19. However, current methods of cell-free …
multiple critical illnesses, including COVID-19. However, current methods of cell-free …