Alcoholic fatty liver disease (AFLD) is one of the most prevalent forms of liver disease
worldwide and can progress to inflammation (hepatitis), fibrosis/cirrhosis, and ultimately lead to …

Lipin‐1 is a Mg 2+ ‐dependent phosphatidic acid phosphohydrolase involved in the
generation of diacylglycerol during synthesis of phospholipids and triglycerides. Ethanol‐mediated …

Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes
generation of proinflammatory cytokines in Kupffer cells, causing hepatic inflammation. Among …

We have previously shown that the ethanol-mediated elevation of lipocaline-2 (LCN2) is
closely associated with the development of alcoholic fatty liver disease (AFLD) in mice. Herein, …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial
remodeling and pulmonary dysfunction. The etiology of IPF is not completely understood but …

Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule
involved in various signaling pathways via its function as a PAP enzyme in the triglyceride …

MitoNEET (mNT) (CDGSH iron-sulfur domain-containing protein 1 or CISD1) is an outer
mitochondrial membrane protein that donates 2Fe-2S clusters to apo-acceptor proteins. In the …

The splenic microenvironment regulates hematopoietic stem and progenitor cell (HSPC)
function, particularly during demand-adapted hematopoiesis; however, practical strategies to …

Lipin-1 is a phosphatidate phosphohydrolase (PAP) required for the generation of
diacylglycerol during glycerolipid synthesis, and exhibits dual functions in the regulation of lipid …

Alcoholic liver disease (ALD) is the most prevalent form of liver disease, encompassing a
spectrum of progressive pathological changes from steatosis to steatohepatitis to fibrosis/…