Tissue stiffening is a hallmark of fibrotic disorders but has traditionally been regarded as an
outcome of fibrosis, not a contributing factor to pathogenesis. In this study, we show that …

Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor
cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in …

From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of
close-packed collective systems—both inert and living—have the potential to jam. The …

Background Tracking longitudinal measurements of growth and decline in lung function in
patients with persistent childhood asthma may reveal links between asthma and subsequent …

Astrocytomas, oligodendrogliomas, and oligoastrocytomas, collectively referred to as diffuse
gliomas, are the most common primary brain tumors. These tumors are classified by …

The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin
gene leading to the absence of the corresponding RNA transcript and protein. Absence of …

Macrophages serve to maintain organ homeostasis in response to challenges from injury,
inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has …

Three years ago, when a colleague would approach us with questions about functional
genomics and the informatics techniques required to leverage the data obtained from …

Identification of common mechanisms underlying organ development and primary tumor
formation should yield new insights into tumor biology and facilitate the generation of relevant …

Rationale: Current understanding of the molecular regulation of lung development is limited
and derives mostly from animal studies. Objectives: To define global patterns of gene …