User profiles for Aly Khan
 | Aly Azeem KhanUniversity of Chicago, 23andMe Verified email at uchicago.edu Cited by 6762 |
[PDF][PDF] Gender bias in autoimmunity is influenced by microbiota
L Yurkovetskiy, M Burrows, AA Khan, L Graham… - Immunity, 2013 - cell.com
Gender bias and the role of sex hormones in autoimmune diseases are well established. In
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
Transfection of small RNAs (such as small interfering RNAs (siRNAs) and microRNAs (miRNAs))
into cells typically lowers expression of many genes. Unexpectedly, increased …
into cells typically lowers expression of many genes. Unexpectedly, increased …
Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants
…, L Paparo, R Aitoro, A Calignano, AA Khan… - The ISME …, 2016 - academic.oup.com
Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus
rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow’s …
rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow’s …
[PDF][PDF] Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction
…, JM Chen, P Manning, GM Steiner, XC Doan, AA Khan… - Cell, 2020 - cell.com
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the miR-17–92
cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and …
cluster, containing six individual miRNAs, is highly expressed in haematopoietic cancers and …
[PDF][PDF] Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA
targets remains a major challenge. Most target prediction and discovery relies on perfect …
targets remains a major challenge. Most target prediction and discovery relies on perfect …
A genomic regulatory element that directs assembly and function of immune-specific AP-1–IRF complexes
Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi…
differentiation. They are recruited to cis-regulatory Ets-IRF composite elements by PU.1 or Spi…
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)
The importance of individual microRNAs (miRNAs) has been established in specific cancers.
However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of …
However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of …
Predicting protein–protein interactions through sequence-based deep learning
Motivation High-throughput experimental techniques have produced a large amount of
protein–protein interaction (PPI) data, but their coverage is still low and the PPI data is also very …
protein–protein interaction (PPI) data, but their coverage is still low and the PPI data is also very …
Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation
CD11b + dendritic cells (DCs) seem to be specialized for presenting antigens via major
histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and …
histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and …