In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines. …

Strain-induced adaption of bone has been well-studied in an axial loading model of the
mouse tibia. However, most outcomes of these studies are restricted to changes in bone …

Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis
of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial …

Abdominal aortic aneurysm (AAA) formation and expansion is highly complex and
multifactorial, and the improvement of animal models is an important step to enhance our …

Dysregulation of skeletal remodeling is a component of renal osteodystrophy. Previously, we
showed that activin receptor signaling is differentially affected in various tissues in chronic …

Tissue engineered vascular grafts (TEVGs) using scaffolds fabricated from braided poly(glycolic
acid) (PGA) fibers coated with poly(glycerol sebacate) (PGS) are developed. The …

… Mice deficient in cardiac Cpt2 (Cpt2M / ; n 5; age 11.2 weeks; body mass 20.1 [0.71] g),
hereafter referred to as the Cpt2M/ cohort, have impaired cardiomyocyte fatty acid oxidative …

Recent applications of computational fluid dynamics (CFD) applied to the cardiovascular
system have demonstrated its power in investigating the impact of hemodynamics on disease …

With approximately 48,000 attributed deaths in 2017, the opioid overdose is now the leading
cause of death amongst Americans under the age of 50. The overdose process can be …

Scope Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is
characterized by a spectrum of phenotypes including skeletal abnormalities. The Ts65Dn DS …