Background Long noncoding RNAs (lncRNAs) form an abundant class of transcripts, but the
function of the majority of them remains elusive. While it has been shown that some …

Slowing down translation in either the cytosol or the mitochondria is a conserved longevity
mechanism. Here, we found a non-interventional natural correlation of mitochondrial and …

Zebrafish carrying heterozygous mutations for 17 different ribosomal protein (rp) genes are
prone to developing malignant peripheral nerve sheath tumors (MPNSTs), a tumor type that …

Ribosomal protein (RP) gene mutations, mostly associated with inherited or acquired bone
marrow failure, are believed to drive disease by slowing the rate of protein synthesis. Here de …

Diamond-Blackfan anemia (DBA) is a rare congenital erythroblastopenia and inherited bone
marrow failure syndrome that affects approximately seven individuals in every million live …

The deregulation of metabolism is a hallmark of aging. As such, changes in the expression
of metabolic genes and the profiles of amino acid levels are features associated with aging …

Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1)
pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is …

Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with
phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-…

Dyskeratosis congenita (DC) is a bone marrow failure disorder characterized by shortened
telomeres, defective stem cell maintenance, and highly heterogeneous phenotypes affecting …

Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting
mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by …