We recently described a human marker chromosome containing a functional neo-centromere
that binds anti-centromere antibodies, but is devoid of centromeric α-satellite repeats and …

Var genes encode the major surface antigen (PfEMP1) of the blood stages of the human
malaria parasite Plasmodium falciparum. Differential expression of up to 60 diverse var genes …

Plasmodium vivax is a major public health burden, responsible for the majority of malaria
infections outside Africa. We explored the impact of demographic history and selective …

The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …

Genetic variability of Plasmodium falciparum underlies its transmission success and thwarts
efforts to control disease caused by this parasite. Genetic variation in antigenic, drug …

A better understanding of human-to-mosquito transmission is crucial to control malaria. In
order to assess factors associated with gametocyte carriage, 2083 samples were collected in a …

Traditionally, infection with Plasmodium vivax was thought to be benign and self-limiting,
however, recent evidence has demonstrated that infection with P. vivax can also result in …

A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

After more than 50 years of intensive research and development, only one malaria vaccine
candidate, “RTS,S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy, this …

Introduction Solomon Islands is intensifying national efforts to achieve malaria elimination.
A long history of indoor spraying with residual insecticides, combined recently with …