[PDF][PDF] Interdigitation between triglycerides and lipids modulates surface properties of lipid droplets

A Bacle, R Gautier, CL Jackson, PFJ Fuchs, S Vanni - Biophysical journal, 2017 - cell.com
Intracellular lipid droplets (LDs) are the main cellular site of metabolic energy storage. Their
structure is unique inside the cell, with a core of esterified fatty acids and sterols, mainly …

Inverse conformational selection in lipid–protein binding

A Bacle, P Buslaev, R Garcia-Fandino… - Journal of the …, 2021 - ACS Publications
Interest in lipid interactions with proteins and other biomolecules is emerging not only in
fundamental biochemistry but also in the field of nanobiotechnology where lipids are commonly …

[PDF][PDF] PackMem: a versatile tool to compute and visualize interfacial packing defects in lipid bilayers

R Gautier, A Bacle, ML Tiberti, PF Fuchs, S Vanni… - Biophysical journal, 2018 - cell.com
The analysis of the structural organization of lipid bilayers is generally performed across the
direction normal to the bilayer/water interface, whereas the surface properties of the bilayer …

Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome

…, M Carpentier, K Ramji, K Ben Mbarek, A Bacle… - Journal of Cell …, 2022 - rupress.org
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …

[HTML][HTML] Cooperation of conical and polyunsaturated lipids to regulate initiation and processing of membrane fusion

C François-Martin, A Bacle, JE Rothman… - Frontiers in Molecular …, 2021 - frontiersin.org
The shape of lipids has long been suspected to be a critical determinant for the control of
membrane fusion. To experimentally test this assertion, we used conical and malleable lipids …

Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin

AM Taxt, Y Diaz, A Bacle, C Grauffel… - Infection and …, 2014 - Am Soc Microbiol
Enterotoxigenic Escherichia coli (ETEC) expressing the heat-stable toxin (ST) (human-type [STh]
and porcine-type [STp] variants) is among the five most important enteric pathogens in …

A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction

A Bacle, L Kadri, S Khoury… - Disease models & …, 2020 - journals.biologists.com
The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated
or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular …

[HTML][HTML] Polyunsaturated phospholipids increase cell resilience to mechanical constraints

L Kadri, A Bacle, S Khoury, C Vandebrouck, J Bescond… - Cells, 2021 - mdpi.com
If polyunsaturated fatty acids (PUFAs) are generally accepted to be good for health, the
mechanisms of their bona fide benefits still remain elusive. Membrane phospholipids (PLs) of the …

[HTML][HTML] Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

L Kadri, R Ferru-Clément, A Bacle, LA Payet… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Maintaining the equilibrium between saturated and unsaturated fatty acids within membrane
phospholipids (PLs) is crucial to sustain the optimal membrane biophysical properties, …

Etude in silico des gouttelettes lipidiques et de leur interaction avec des protéines périphériques via des hélices amphipathiques

A Bacle - 2016 - theses.fr
Les gouttelettes lipidiques (GL) sont des organites intracellulaire qui jouent un rôle central
dans le métabolisme des lipides. Elles sont également impliquées dans des maladies telles …