Actin cytoskeleton is well-known for providing structural/mechanical support, but whether
and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report …

Yes-associated protein (YAP) is known to promote the stemness of multiple stem cell types,
including pluripotent stem cells, while also antagonizing pluripotency during early …

Cancer is a hyper-proliferative disease. Whether the proliferative state originates from the
cell-of-origin or emerges later remains difficult to resolve. By tracking de novo transformation …

A close relationship between proliferation and cell fate specification has been well
documented in many developmental systems. In addition to the gradual cell fate changes …

Cell proliferation changes concomitantly with fate transitions during reprogramming, differentiation,
regeneration, and oncogenesis. Methods to resolve cell cycle length heterogeneity in …

There is wide variability in the propensity of somatic cells to reprogram into pluripotency in
response to the Yamanaka factors. How to segregate these variabilities to enrich for cells of …

As somatic cell reprogramming to pluripotency is inefficient, the majority of cells in the culture
fail to attain pluripotency. The contribution of the failed “bystander” cells to the emerging …

Periodicity is a fundamental property of biological oscillators such as the mitotic cell cycle. In
this context, periodicity refers to the time interval between the same phases of two …

Publisher Correction: MLL-AF9 initiates transformation from fast-proliferating myeloid
progenitors - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

The conventional view of oncogenesis posits that driver mutations, when present in appropriate
cell types, initiate malignant transformation. At the apex of the differentiation hierarchy, …