US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Background: Risk for venous thromboembolism has a strong genetic component. Whole
genome sequencing from the TOPMed program (Trans-Omics for Precision Medicine) allowed …

QT interval prolongation is a heritable risk factor for ventricular arrhythmias and can predispose
to sudden death. Most genome-wide association studies (GWAS) of QT were performed …

Background: QT interval (QT) prolongation is an established risk factor for ventricular
tachyarrhythmia and sudden cardiac death. Previous genome-wide association studies in …

Background The electrocardiographically measured QT interval (QT) is heritable and its
prolongation is an established risk factor for several cardiovascular diseases. Yet, most QT …

Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been
associated with an increased risk of cardiovascular disease. Their effects on QT interval …

506 human genome [17]. The availability of large-scale GWAS greatly increased the coverage
of candidate gene studies, which typically evaluated a small number of SNPs in a handful …

Objective PR interval (PR) is a heritable electrocardiographic measure of atrial and atrioventricular
nodal conduction. Changes in PR duration may be associated with atrial fibrillation, …

Background The electrocardiographically quantified QRS duration measures ventricular
depolarization and conduction. QRS prolongation has been associated with poor heart failure …

Objective To evaluate the impact of post-diagnostic metformin or statin use and duration on
risk of biochemical recurrence in a racially-diverse cohort of Veterans. Methods The …