[HTML][HTML] Principles and approaches for reproducible scoring of tissue stains in research
DK Meyerholz, AP Beck - Laboratory investigation, 2018 - Elsevier
Abstract Evaluation of tissues is a common and important aspect of translational research
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to enhance …
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to enhance …
Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice
…, SK Libutti, Z Yuan, J Li, S Siddiqui, A Beck… - Science translational …, 2022 - science.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …
[PDF][PDF] The xenobiotic transporter Mdr1 enforces T cell homeostasis in the presence of intestinal bile acids
…, A Sun, SY Kim, ES Rangarajan, K McKevitt, AP Beck… - Immunity, 2017 - cell.com
CD4 + T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells
interface with host-derived metabolites is less clear. Here, we show that CD4 + T effector (…
interface with host-derived metabolites is less clear. Here, we show that CD4 + T effector (…
Opportunistic financial reporting around municipal bond issues
AW Beck - Review of Accounting Studies, 2018 - Springer
Understanding how government officials exercise discretion over financial reporting is essential
for citizens, regulators, and researchers to interpret and monitor financial performance. I …
for citizens, regulators, and researchers to interpret and monitor financial performance. I …
Fundamental concepts for semiquantitative tissue scoring in translational research
DK Meyerholz, AP Beck - ILAR journal, 2018 - academic.oup.com
Failure to reproduce results from some scientific studies has raised awareness of the critical
need for reproducibility in translational studies. Macroscopic and microscopic examination is …
need for reproducibility in translational studies. Macroscopic and microscopic examination is …
Genomic events associated with progression of pleural malignant mesothelioma
Pleural malignant mesothelioma (MM) is an aggressive cancer with a very long latency and
a very short median survival. Little is known about the genetic events that trigger MM and …
a very short median survival. Little is known about the genetic events that trigger MM and …
[HTML][HTML] 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
…, J Arasa, R Fernandez-Rodriguez, A Beck… - Nature …, 2021 - nature.com
Tryptophan catabolism is a major metabolic pathway utilized by several professional and
non-professional antigen presenting cells to maintain immunological tolerance. Here we report …
non-professional antigen presenting cells to maintain immunological tolerance. Here we report …
Are audit-related factors associated with financial reporting quality in nonprofit organizations?
SA Garven, AW Beck… - Auditing: A Journal of …, 2018 - publications.aaahq.org
We examine the effects of several audit-related factors on nonprofit financial reporting quality
(FRQ). Using four different measures of FRQ, we demonstrate that the findings of nonprofit …
(FRQ). Using four different measures of FRQ, we demonstrate that the findings of nonprofit …
Targeting the pregnane X receptor using microbial metabolite mimicry
…, WG Walton, MR Redinbo, K Sun, A Beck… - EMBO molecular …, 2020 - embopress.org
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential
roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have …
roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have …
[HTML][HTML] 32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect
Our laboratory has developed a novel delivery platform using an attenuated non-toxic and
non-pathogenic bacterium Listeria monocytogenes that infects tumor cells and selectively …
non-pathogenic bacterium Listeria monocytogenes that infects tumor cells and selectively …