The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part
of its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein, …

Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet
activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI …

Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged
immune response in the brain may cause neurodegeneration, resulting in chronic …

Necroptotic cell death has been implicated in many human pathologies and is thought to
have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the …

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2
(NRF2) signaling pathway senses reactive oxygen species and regulates cellular oxidative …

Necroptosis is a form of caspase-independent programmed cell death that arises from disruption
of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after …

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral
treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2. …

The circulating life span of blood platelets is regulated by the prosurvival protein BCL-X L . It
restrains the activity of BAK and BAX, the essential prodeath mediators of intrinsic apoptosis…

Platelets have been shown to enhance the survival of lymphoma cell lines. However, it remains
unclear whether they play a role in lymphoma. Here, we investigated the potential role of …

Background Traumatic brain injury (TBI) is known to promote immunosuppression, making
patients more susceptible to infection, yet potentially exerting protective effects by inhibiting …