Study objective Although the World Health Organization recommends take-home naloxone
to address the increasing global burden of opioid-related deaths, few emergency …

Background Immune checkpoint inhibitors (ICIs) demonstrate unprecedented efficacy in
multiple malignancies; however, the mechanisms of sensitivity and resistance are poorly …

Background Human leukocyte antigen class 1 (HLA-1)–dependent immune activity is linked
to autoimmune diseases. HLA-1–dependent CD8 + T cells are required for immune …

Here we report on a new fossil locality, Şerefköy-2, from the Yatağan Basin of southwestern
Turkey that preserves a well-sampled, abundant, and diverse mammal fauna. Indeed, after …

ObjectiveTake-home naloxone (THN) reduces deaths from opioid overdose. To increase
THN distribution to at-risk emergency department (ED) patients, we explored reasons for …

Background Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing cancers
that often present with local and distant metastasis upon detection. PANETS contain distinct …

Introduction The emergence of COVID-19 introduced a dual public health emergency in British
Columbia, which was already in the fourth year of its opioid-related overdose crisis. The …

Background Asthma and obesity, two growing epidemics worldwide, may share an underlying
causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, …

While comparison of primary tumor and metastases has highlighted genomic heterogeneity
in colorectal cancer (CRC), previous studies have focused on a single metastatic site or …

Airway smooth muscle cells produce extracellular matrix proteins, which in turn can promote
smooth muscle survival, proliferation and migration. Currently available therapies have little …