User profiles for Amanda J. Lea

Amanda J. Lea

Vanderbilt University
Verified email at vanderbilt.edu
Cited by 1878

Genome-wide quantification of the effects of DNA methylation on human gene regulation

AJ Lea, CM Vockley, RA Johnston, CA Del Carpio… - elife, 2018 - elifesciences.org
10.7554/eLife.37513.001 Changes in DNA methylation are involved in development, disease,
and the response to environmental conditions. However, not all regulatory elements are …

High social status males experience accelerated epigenetic aging in wild baboons

JA Anderson, RA Johnston, AJ Lea, FA Campos… - Elife, 2021 - elifesciences.org
Aging, for virtually all life, is inescapable. However, within populations, biological aging
rates vary. Understanding sources of variation in this process is central to understanding the …

Developmental plasticity: bridging research in evolution and human health

AJ Lea, J Tung, EA Archie… - Evolution, medicine, and …, 2017 - academic.oup.com
Early life experiences can have profound and persistent effects on traits expressed throughout
the life course, with consequences for later life behavior, disease risk, and mortality rates. …

Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana

AJ Lea, D Martins, J Kamau, M Gurven, JF Ayroles - Science Advances, 2020 - science.org
The “mismatch” between evolved human physiology and Western lifestyles is thought to
explain the current epidemic of cardiovascular disease (CVD) in industrialized societies. …

[HTML][HTML] A flexible, efficient binomial mixed model for identifying differential DNA methylation in bisulfite sequencing data

AJ Lea, J Tung, X Zhou - PLoS genetics, 2015 - journals.plos.org
Identifying sources of variation in DNA methylation levels is important for understanding gene
regulation. Recently, bisulfite sequencing has become a popular tool for investigating DNA …

Heritable victimization and the benefits of agonistic relationships

AJ Lea, DT Blumstein, TW Wey… - Proceedings of the …, 2010 - National Acad Sciences
Here, we present estimates of heritability and selection on network traits in a single
population, allowing us to address the evolutionary potential of social behavior and the poorly …

Resource base influences genome‐wide DNA methylation levels in wild baboons (Papio cynocephalus)

AJ Lea, J Altmann, SC Alberts, J Tung - Molecular ecology, 2016 - Wiley Online Library
Variation in resource availability commonly exerts strong effects on fitness‐related traits in
wild animals. However, we know little about the molecular mechanisms that mediate these …

Developmental constraints in a wild primate

AJ Lea, J Altmann, SC Alberts… - The American …, 2015 - journals.uchicago.edu
Early-life experiences can dramatically affect adult traits. However, the evolutionary origins
of such early-life effects are debated. The predictive adaptive response hypothesis argues …

Heterospecific eavesdropping in a nonsocial species

AJ Lea, JP Barrera, LM Tom, DT Blumstein - Behavioral Ecology, 2008 - academic.oup.com
Many species respond to heterospecific alarm calls, and the majority are social taxa and
possess complex alarm calls themselves. Thus, the ability to respond to heterospecific alarm …

Complex sources of variance in female dominance rank in a nepotistic society

AJ Lea, NH Learn, MJ Theus, J Altmann, SC Alberts - Animal behaviour, 2014 - Elsevier
Many mammalian societies are structured by dominance hierarchies, and an individual's
position within this hierarchy can influence reproduction, behaviour, physiology and health. In …