User profiles for Amanda J. Pickard
Amanda PickardMemorial Sloan Kettering Cancer Center Verified email at mskcc.org Cited by 2094 |
Microbiota modulate sympathetic neurons via a gut–brain circuit
Connections between the gut and brain monitor the intestinal tissue and its microbial and
dietary content 1 , regulating both physiological intestinal functions such as nutrient absorption …
dietary content 1 , regulating both physiological intestinal functions such as nutrient absorption …
Commensal bacteria make GPCR ligands that mimic human signalling molecules
Commensal bacteria are believed to have important roles in human health. The mechanisms
by which they affect mammalian physiology remain poorly understood, but bacterial …
by which they affect mammalian physiology remain poorly understood, but bacterial …
Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT
Respiratory viral infections are frequent in patients undergoing allogeneic hematopoietic
stem cell transplantation (allo-HCT) and can potentially progress to lower respiratory tract …
stem cell transplantation (allo-HCT) and can potentially progress to lower respiratory tract …
[HTML][HTML] Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification
Klebsiella pneumoniae, Escherichia coli, and other members of the Enterobacteriaceae family
are common human pathogens that have acquired broad antibiotic resistance, rendering …
are common human pathogens that have acquired broad antibiotic resistance, rendering …
The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD
Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic
hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early …
hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early …
[PDF][PDF] Mapping interactions of microbial metabolites with human G-protein-coupled receptors
…, JA Kohn, PM Luo, FJ Piscotta, SM Han, AJ Pickard… - Cell host & …, 2019 - cell.com
Despite evidence linking the human microbiome to health and disease, how the microbiota
affects human physiology remains largely unknown. Microbiota-encoded metabolites are …
affects human physiology remains largely unknown. Microbiota-encoded metabolites are …
[PDF][PDF] Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice
…, MD Docampo, Y Shono, B Durham, AJ Pickard… - Cell host & …, 2018 - cell.com
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk
hematologic malignancies, but the post-transplantation period is characterized by profound …
hematologic malignancies, but the post-transplantation period is characterized by profound …
Comparison of topical and intravenous tranexamic acid for total knee replacement: a randomized double-blinded controlled study of effects on tranexamic acid levels …
Background: Tranexamic acid (TXA) is an antifibrinolytic drug. Topical administration of TXA
during total knee arthroplasty (TKA) is favored for certain patients because of concerns …
during total knee arthroplasty (TKA) is favored for certain patients because of concerns …
The cell's nucleolus: an emerging target for chemotherapeutic intervention
AJ Pickard, U Bierbach - ChemMedChem, 2013 - Wiley Online Library
The transient nucleolus plays a central role in the up‐regulated synthesis of ribosomal RNA
(rRNA) to sustain ribosome biogenesis, a hallmark of aberrant cell growth. This function, in …
(rRNA) to sustain ribosome biogenesis, a hallmark of aberrant cell growth. This function, in …
Redesigning the DNA‐Targeted Chromophore in Platinum–Acridine Anticancer Agents: A Structure–Activity Relationship Study
Platinum–acridine hybrid agents show low‐nanomolar potency in chemoresistant non‐small
cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous …
cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous …