User profiles for Amanda J. Pickard

Amanda Pickard

Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 2094

Microbiota modulate sympathetic neurons via a gut–brain circuit

…, M Furuichi, M Perkins, W Han, A Rao, AJ Pickard… - Nature, 2020 - nature.com
Connections between the gut and brain monitor the intestinal tissue and its microbial and
dietary content 1 , regulating both physiological intestinal functions such as nutrient absorption …

Commensal bacteria make GPCR ligands that mimic human signalling molecules

…, AJ Pickard, JR Cross, AB Emiliano, SM Han, J Chu… - Nature, 2017 - nature.com
Commensal bacteria are believed to have important roles in human health. The mechanisms
by which they affect mammalian physiology remain poorly understood, but bacterial …

Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT

…, ER Littmann, JL Chaubard, AJ Pickard… - Blood, The Journal …, 2018 - ashpublications.org
Respiratory viral infections are frequent in patients undergoing allogeneic hematopoietic
stem cell transplantation (allo-HCT) and can potentially progress to lower respiratory tract …

[HTML][HTML] Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification

…, AJ Bäumler, JL Chaubard, AJ Pickard… - Journal of Experimental …, 2019 - rupress.org
Klebsiella pneumoniae, Escherichia coli, and other members of the Enterobacteriaceae family
are common human pathogens that have acquired broad antibiotic resistance, rendering …

The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

…, ALC Gomes, ER Littmann, AJ Pickard… - Blood, The Journal …, 2020 - ashpublications.org
Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic
hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early …

[PDF][PDF] Mapping interactions of microbial metabolites with human G-protein-coupled receptors

…, JA Kohn, PM Luo, FJ Piscotta, SM Han, AJ Pickard… - Cell host & …, 2019 - cell.com
Despite evidence linking the human microbiome to health and disease, how the microbiota
affects human physiology remains largely unknown. Microbiota-encoded metabolites are …

[PDF][PDF] Nutritional support from the intestinal microbiota improves hematopoietic reconstitution after bone marrow transplantation in mice

…, MD Docampo, Y Shono, B Durham, AJ Pickard… - Cell host & …, 2018 - cell.com
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk
hematologic malignancies, but the post-transplantation period is characterized by profound …

Comparison of topical and intravenous tranexamic acid for total knee replacement: a randomized double-blinded controlled study of effects on tranexamic acid levels …

…, TP Sculco, LR Baaklini, AS McLawhorn, AJ Pickard… - JBJS, 2019 - journals.lww.com
Background: Tranexamic acid (TXA) is an antifibrinolytic drug. Topical administration of TXA
during total knee arthroplasty (TKA) is favored for certain patients because of concerns …

The cell's nucleolus: an emerging target for chemotherapeutic intervention

AJ Pickard, U Bierbach - ChemMedChem, 2013 - Wiley Online Library
The transient nucleolus plays a central role in the up‐regulated synthesis of ribosomal RNA
(rRNA) to sustain ribosome biogenesis, a hallmark of aberrant cell growth. This function, in …

Redesigning the DNA‐Targeted Chromophore in Platinum–Acridine Anticancer Agents: A Structure–Activity Relationship Study

AJ Pickard, F Liu, TF Bartenstein… - … A European Journal, 2014 - Wiley Online Library
Platinum–acridine hybrid agents show low‐nanomolar potency in chemoresistant non‐small
cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous …