Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Fragment-based drug discovery (FBDD) is a technique for identifying low molecular weight
chemical starting points for drug discovery. Since its inception 20 years ago, FBDD has …

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC protein …

Human immunodeficiency virus (HIV)-1 is able to replicate in primary human macrophages
without stimulating innate immunity despite reverse transcription of genomic RNA into double…

The Mixed Lineage Leukemia (Mll) gene is a homolog of Drosophila Trithorax commonly
rearranged in infant leukemia. Comprehensive analysis of the role of Mll in hematopoiesis in …

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in
CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However, …

During the early stages of infection, the HIV-1 capsid protects viral components from cytosolic
sensors and nucleases such as cGAS and TREX, respectively, while allowing access to …

The hippocampus formation, although prominently implicated in schizophrenia pathogenesis,
has been overlooked in large-scale genomics efforts in the schizophrenic brain. We …

The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of
the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T …