Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK (…

How viruses evolve within hosts can dictate infection outcomes; however, reconstructing
this process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …

Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …

Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities
1 , 2 . In July 2016, mosquito-borne ZIKV transmission was reported in the continental …

For decades, human infections with Zika virus (ZIKV), a mosquito‐transmitted flavivirus,
were sporadic, associated with mild disease, and went underreported since symptoms were …

Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a …

The Zika epidemic in the Americas has challenged surveillance and control. As the
epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is …

Metagenomic sequencing has the potential to transform microbial detection and
characterization, but new tools are needed to improve its sensitivity. We developed CATCH (Compact …

The ongoing Zika epidemic in the Americas has challenged public health surveillance,
response, and control systems. Even as the epidemic appears to be near its end in the Americas, …

Despite great attention given to the recent Zika virus (ZIKV) epidemic in the Americas, much
remains unknown about its epidemiology and evolution, in part due to a lack of genomic data…