Restriction of food intake increases the acquisition of drug abuse behavior and enhances
the reinforcing efficacy of those drugs. However, the neurophysiological mechanisms …

Background: Methamphetamine is a psychomotor stimulant with abuse liability and a substrate
for catecholamine uptake transporters. Acute methamphetamine elevates extracellular …

Like humans with sleep apnea, rats exposed to chronic intermittent hypoxia (CIH) experience
arterial hypoxemias and develop hypertension characterized by exaggerated sympathetic …

Models of ethanol self‐administration in animals have demonstrated that ethanol can reinforce
a variety of behaviors, independent of ethanol's caloric or fluid properties. However, the …

The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure
is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the …

Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still being
determined after previously being thought to be absent from the brain. MHC-I expression …

Epigenetic regulation of gene expression occurs in a cell type-specific manner. Current cell-type
specific neuroepigenetic studies rely on cell sorting methods that can alter cell …

Rationale: The concepts of appetitive and consummatory behaviors provide a framework for
examining ethanol-drinking behavior. However, traditional studies of ethanol self-…

Background: Although previous murine studies have demonstrated ethanol self‐administration
resulting in blood ethanol concentrations (BECs) believed to be pharmacologically …

Rationale Obesity is a major health problem worldwide. An understanding of the factors that
drive feeding behaviors is key to the development of pharmaceuticals to decrease appetite …