The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus
disease 2019 (COVID‐19) pandemic, has spread worldwide since it was first identified in …

Chagas disease, the parasitic infection caused by Trypanosoma cruzi, afflicts about 6 million
people in Latin America. Here, we investigated the hypothesis that T. cruzi may fuel heart …

High Mobility Group protein 1 (HMGB1) is a non-histone, chromatin-associated nuclear
protein that functions in regulating eukaryotic gene expression. We investigated the influence …

The mosquito Aedes aegypti can spread the dengue, chikungunya and yellow fever viruses.
Thus, the search for key molecules involved in the mosquito survival represents today a …

Epigenetic mechanisms are responsible for a wide range of biological phenomena in insects,
controlling embryonic development, growth, aging and nutrition. Despite this, the role of …

Background 3-(3-chloro-phenyl)-5-(4-pyridyl)-4,5-dihydroisoxazole (DIC) is a five-membered
heterocyclic compound containing a NO bond. The anti-inflammatory effects of this …

Background Transfusion‐transmitted malaria (TTM) is a public health problem in endemic
and nonendemic areas. The Brazilian Ministry of Health (MH) requested the development of a …

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ)
and, due to mass treatment, the increasing risk of selecting for schistosome strains that …

SARS-CoV-2, the causative agent of the ongoing COVID-19, has spread worldwide since it
was first identified in November 2019 in Wuhan. Since then, it was already demonstrated an …

The Schistosoma mansoni High Mobility Group Box (HMGB) proteins SmHMGB1, SmHMGB2
and SmHMGB3 share highly conserved HMG box DNA binding domains but have …