Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly
understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-…

COVID-19 has caused over 1 million deaths globally, yet the cellular mechanisms underlying
severe disease remain poorly understood. By analyzing several thousand plasma proteins …

Functional selectivity at the µ opioid receptor (µR), a prototypical G-protein–coupled receptor
that is a physiologically relevant target for endogenous opioid neurotransmitters and …

Endotoxin—bacterial lipopolysaccharide (LPS)—is a driver of lethal infection sepsis through
excessive activation of innate immune responses. When delivered to the cytosol of …

Membrane trafficking and receptor signaling are two fundamental cellular processes that
interact constantly. Although how trafficking regulates signaling is well studied, how signaling …

Inflammasomes are cytosolic supramolecular organizing centers that, in response to
pathogen-derived molecules and endogenous danger signals, assemble and activate innate …

In the last months, many studies have clearly described several mechanisms of SARS-CoV-2
infection at cell and tissue level. Host conditions and comorbidities were identified as risk …

Heterogeneous immunoassays such as ELISA have become indispensable in modern
bioanalysis, yet translation into easy-to-use point-of-care assays is hindered by their dependence …

Background: Safe and effective patient care depends on the teamwork of multidisciplinary
healthcare professionals. Unfortunately, the field currently lacks an evidence-based …

Objective: The purpose of this meta-analytic review is to examine the role of three work
environment support variables (ie, peer, supervisor, and organizational support) in training …