Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Most accelerator-based space radiation experiments have been performed with single ion
beams at fixed energies. However, the space radiation environment consists of a wide variety …

Copy-number variants of chromosome 16 region 16p11.2 are linked to neuropsychiatric
disorders 1 , 2 , 3 , 4 , 5 , 6 and are among the most prevalent in autism spectrum disorders 1 , 2 …

While stressful life events are an important cause of psychopathology, most individuals
exposed to adversity maintain normal psychological functioning. The molecular mechanisms …

Deficiency in fragile X mental retardation protein (FMRP) results in fragile X syndrome (FXS),
an inherited form of intellectual disability. Despite extensive research, it is unclear how …

10.7554/eLife.25730.001 Sequencing studies have implicated haploinsufficiency of ARID1B,
a SWI/SNF chromatin-remodeling subunit, in short stature (Yu et al., 2015), autism …

Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may
contribute to the pathophysiology of depression. The aim of this study was to investigate the …

Recent work implicates regulation of neurogenesis as a form of plasticity in the adult rat
hippocampus. Given the known effects of opiates such as morphine and heroin on hippocampal …

Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation
and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a …

The transcription factor cAMP response element (CRE)-binding protein (CREB) has been
shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, …