The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …

Rejection remains the main cause of premature graft loss after kidney transplantation, despite
the use of potent immunosuppression. This highlights the need to better understand the …

Background Immune checkpoint inhibitor (ICI)-related pneumonitis is the most frequent fatal
immune-related adverse event associated with programmed cell death protein-1/…

Cancer patients often receive a combination of antibodies targeting programmed death-ligand
1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-…

Objectives Immune checkpoint inhibitors (ICI) have introduced a new era in the treatment of
recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC). Optimal …

6081 Background: Promising rates of response to ICI have been observed in patients with
OSCC. This is phase I/II study with focus on biological changes observed in sequential tissue …

The tumor microenvironment (TME) shapes response to immune checkpoint blockade (ICB).
Several pan-cancer single-cell RNA-sequencing (scRNA-seq) analyses have reported how …

The body's natural defense system is designed to recognize and eliminate altered or foreign
cells, including cancerous ones. However, cancer cells can occasionally evade this system, …

Contemporary society is plagued by a number of issues and inconsistencies on both an
environmental and a socio-economic level. Reliance on bank loans forces debtors to seek …

Conclusions: We report the real-world impact of a change from PCV1 3 to PCVI 0. Two to
three year after the vaccine switch, a re-emergence of ST1 9A IPD in children< 2 years is …