Peroxisome proliferator-activated receptor-γ (PPAR-γ) has essential roles in adipogenesis
and glucose homeostasis, and is a molecular target of insulin-sensitizing drugs 1 , 2 , 3 . …

A crucial feature of differentiated cells is the rapid activation of enhancer-driven transcriptional
programs in response to signals. The potential contributions of physicochemical …

A significant current challenge in human genetics is the identification of interacting genetic
loci mediating complex polygenic disorders. One of the best characterized polygenic …

The epigenetic control of neuronal gene expression patterns has emerged as an underlying
regulatory mechanism for neuronal function, identity, and plasticity, in which short- to long-…

… GAMLIEL … Gamliel, A model for optimal annual management of the coastal aquifer in Israel
(in Hebrew), report, … Gamliel, Department of Geology, Kent State University, Kent, OH 44242. …

The eukaryotic genome is partitioned into distinct topological domains separated by
boundary elements. Emerging data support the concept that several well-established nuclear …

Enhancer activation serves as the main mechanism regulating signal-dependent transcriptional
programs, ensuring cellular plasticity, yet central questions persist regarding their …

The peroxisome proliferator‐activated receptor γ (PPARγ) regulates adipocyte differentiation
and glucose homeostasis and is the molecular target of thiazolidinediones (TZDs) that act …

Nuclear receptors induce both transcriptional activation and repression programs responsible
for development, homeostasis, and disease. Here, we report a previously overlooked …

Activation of receptor tyrosine kinases stimulates a diverse array of cellular responses such
as proliferation and differentiation. The first events in the signal transduction pathways …