Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …

Increased flow resistance is responsible for the elevated intraocular pressure characteristic
of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis …

Mammalian cells frequently migrate through tight spaces during normal embryogenesis,
wound healing, diapedesis, or in pathological situations such as metastasis. Nuclear size and …

Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal
partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their …

Nuclear lamins are type V intermediate filament proteins that polymerize into complex
filamentous meshworks at the nuclear periphery and in less structured forms throughout the …

The cause of the elevated outflow resistance and consequent ocular hypertension characteristic
of glaucoma is unknown. To investigate possible causes for this flow resistance, we …

Vimentin is a Type III intermediate filament (VIF) cytoskeletal protein that regulates the
mechanical and migratory behavior of cells. Its expression is considered to be a marker for the …

In development, wound healing, and pathology, cell biomechanical properties are increasingly
recognized as being of central importance. To measure these properties, experimental …

The ability of a cell to regulate its mechanical properties is central to its function. Emerging
evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell …

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …