Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent
cell death events in the body. Here, we present an approach for unbiased determination of …

Type A acute aortic dissection (TAAD) is a disease that has a catastrophic impact on a patient’s
life and emergent surgery represents a key goal of early treatment. Despite continuous …

Detection of cardiomyocyte death is crucial for the diagnosis and treatment of heart disease.
Here we use comparative methylome analysis to identify genomic loci that are unmethylated …

DNA methylation is a fundamental epigenetic mark that governs gene expression and
chromatin organization, thus providing a window into cellular identity and developmental …

Importance Early data revealed a mortality rate of 1% to 2% per hour for type A acute aortic
dissection (TAAAD) during the initial 48 hours. Despite advances in diagnostic testing and …

OBJECTIVES: The management strategy remains controversial for patients presenting with
type A acute aortic dissection with cerebrovascular accident or coma. The present study …

Background Worse outcomes have been reported for women with type A acute aortic dissection
(TAAD). We sought to determine sex-specific operative approaches and outcomes for …

Background Aortic root management in type A acute aortic dissection is controversial. This
study compared outcomes of root replacement (RR) interventions versus more conservative …

Background & Aims Development of nonalcoholic steatohepatitis (NASH) is associated with
reductions in hepatic microRNA122 (MIR122); the RAR related orphan receptor A (RORA) …

Between January 1996 and May 2017, the International Registry on Acute Aortic Dissections
has collected information on a total of 6,424 consecutive patients with acute aortic …