[PDF][PDF] ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
Ribosomes that experience terminal stalls during translation are resolved by ribosome-associated
quality control (QC) pathways that oversee mRNA and nascent chain destruction and …
quality control (QC) pathways that oversee mRNA and nascent chain destruction and …
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2
Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate the anti-tumor
activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that …
activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that …
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-synuclein degradation in α-synucleinopathy models
Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal
intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA …
intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA …
A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans
…, KC Reddy, RJ Luallen, A Fulzele… - Proceedings of the …, 2020 - National Acad Sciences
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we
described a physiological program in the nematode Caenorhabditis elegans called the …
described a physiological program in the nematode Caenorhabditis elegans called the …
[PDF][PDF] Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
…, S Wegmann, HP Wollscheid, RP Wong, A Fulzele… - Molecular Cell, 2024 - cell.com
The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form
polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the …
polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the …
Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA–Protein Interactions
Throughout their cellular lifetime, RNA transcripts are bound to proteins, playing crucial roles
in RNA metabolism, trafficking, and function. Despite the importance of these interactions, …
in RNA metabolism, trafficking, and function. Despite the importance of these interactions, …
BTLA and PD-1 employ distinct phosphatases to differentially repress T cell signaling
T cell-mediated destruction of tumors and virus-infected cells is restricted by co-inhibitory
receptors such as programmed cell death protein 1 (PD-1). Monoclonal antibodies blocking PD-…
receptors such as programmed cell death protein 1 (PD-1). Monoclonal antibodies blocking PD-…
A cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we
described a physiological program in the nematode C. elegans called the Intracellular …
described a physiological program in the nematode C. elegans called the Intracellular …
[CITATION][C] Keratin Profile in Oral Cancer
AG Fulzele - shodhganga.inflibnet.ac.in
… Researcher: Amitkumar Gaibidas Fulzele …
Neurological deterioration in late infantile neuronal ceroid lipofuscinosis
S Worgall, MV Kekatpure, L Heier, D Ballon, JP Dyke… - Neurology, 2007 - AAN Enterprises
Background: Late infantile neuronal ceroid lipofuscinosis (LINCL) is associated with
progressive degeneration of the brain and retina starting in early childhood. Methods: Thirty-two …
progressive degeneration of the brain and retina starting in early childhood. Methods: Thirty-two …