[PDF][PDF] Defining and targeting adaptations to oncogenic KRASG12C inhibition using quantitative temporal proteomics
N Santana-Codina, AS Chandhoke, Q Yu… - Cell reports, 2020 - cell.com
Covalent inhibitors of the KRAS G12C oncoprotein have recently been developed and are
being evaluated in clinical trials. Resistance to targeted therapies is common and may limit …
being evaluated in clinical trials. Resistance to targeted therapies is common and may limit …
[HTML][HTML] The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness
Tumor metastasis profoundly reduces the survival of breast cancer patients, but the mechanisms
underlying breast cancer invasiveness and metastasis are incompletely understood. …
underlying breast cancer invasiveness and metastasis are incompletely understood. …
[HTML][HTML] A novel role for the SUMO E3 ligase PIAS1 in cancer metastasis
…, C Salazar-Arcila, SJ Netherton, AS Chandhoke… - …, 2014 - ncbi.nlm.nih.gov
Tumor metastasis contributes to the grave morbidity and mortality of cancer, but the mechanisms
underlying tumor cell invasiveness and metastasis remain incompletely understood. …
underlying tumor cell invasiveness and metastasis remain incompletely understood. …
PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial–mesenchymal transition
…, Y Ikeuchi, K Karve, A Sarkar, AS Chandhoke… - Cell Death & …, 2021 - nature.com
SUMO E3 ligases specify protein substrates for SUMOylation. The SUMO E3 ligases PIAS1
and TIF1γ target the transcriptional regulator SnoN for SUMOylation leading to suppression …
and TIF1γ target the transcriptional regulator SnoN for SUMOylation leading to suppression …
[HTML][HTML] Identification of a novel link between the protein kinase NDR1 and TGFβ signaling in epithelial cells
I Pot, S Patel, L Deng, AS Chandhoke, C Zhang… - PLoS …, 2013 - journals.plos.org
Transforming growth factor-beta (TGFβ) is a secreted polypeptide that plays essential roles in
cellular development and homeostasis. Although mechanisms of TGFβ-induced responses …
cellular development and homeostasis. Although mechanisms of TGFβ-induced responses …
[PDF][PDF] Interaction between angiotensin converting enzyme (ACE) insertion/deletion and aldosterone synthase (CYP11B2)-344C/T polymorphisms in relation to type 2 …
…, SS Pillai, LJ Abood, AS Chandhoke… - … Journal of Genetics …, 2013 - pdfs.semanticscholar.org
Polymorphism in Renin-Angiotensin-Aldosterone System (RAAS) genes have been studied
extensively in various ethnic groups and largely with inconsistent findings on relationship …
extensively in various ethnic groups and largely with inconsistent findings on relationship …
Identifying Novel SUMO Regulators of TGF Beta-induced EMT and Breast Cancer Invasion
AS Chandhoke - 2016 - prism.ucalgary.ca
Epithelial-mesenchymal transition (EMT) is a fundamental developmental process, which is
reactivated in cancer contributing to tumor invasiveness and metastasis. The secreted factor …
reactivated in cancer contributing to tumor invasiveness and metastasis. The secreted factor …
Abstract C48: Defining mechanisms of adaptation to KRAS G12C inhibitors: Using quantitative proteomics to design combinatorial strategies in pancreatic cancer
N Santana-Codina, AS Chandhoke, Q Yu… - Cancer Research, 2019 - AACR
KRAS is mutated in 95% of pancreatic ductal adenocarcinoma (PDAC) tumors and is a
critical driver of PDAC initiation, survival, and proliferation. Therapeutic efforts to target KRAS …
critical driver of PDAC initiation, survival, and proliferation. Therapeutic efforts to target KRAS …
Correction: PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial–mesenchymal transition
…, Y Ikeuchi, K Karve, A Sarkar, AS Chandhoke… - Cell Death & …, 2021 - nature.com
… Amrita Singh Chandhoke … Amrita Singh Chandhoke … Amrita Singh Chandhoke …
[CITATION][C] Abstract| PDF| Full Text| Supplementary Materials| Order a Reprint| https://doi. org/10.18632/oncoscience. 27
…, C Salazar-Arcila, SJ Netherton, AS Chandhoke…