[HTML][HTML] Changes in gene expression and cellular architecture in an ovarian cancer progression model

AL Creekmore, WT Silkworth, D Cimini, RV Jensen… - PloS one, 2011 - journals.plos.org
Background Ovarian cancer is the fifth leading cause of cancer deaths among women. Early
stage disease often remains undetected due the lack of symptoms and reliable biomarkers. …

[HTML][HTML] Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter

G Zheng, G Victor Fon, W Meixner, A Creekmore… - Scientific reports, 2017 - nature.com
Chronic stress and elevated glucocorticoid hormone are associated with decreases in the
intestinal epithelial tight junction protein claudin-1 (CLDN1). Human/rat CLDN1 promoters …

Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction

AL Creekmore, S Hong, S Zhu, J Xue, JW Wiley - Pain, 2018 - journals.lww.com
In humans, chronic psychological stress is associated with increased intestinal paracellular
permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent …

[HTML][HTML] 3D shape modeling for cell nuclear morphological analysis and classification

…, JR de Wet, GA Higgins, G Zheng, A Creekmore… - Scientific reports, 2018 - nature.com
Quantitative analysis of morphological changes in a cell nucleus is important for the
understanding of nuclear architecture and its relationship with pathological conditions such as …

Structural and functional alterations in the colonic microbiome of the rat in a model of stress induced irritable bowel syndrome

NH Fourie, D Wang, SK Abey, AL Creekmore… - Gut …, 2017 - Taylor & Francis
Stress is known to perturb the microbiome and exacerbate irritable bowel syndrome (IBS)
associated symptoms. Characterizing structural and functional changes in the microbiome is …

The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor α mediated gene expression

AL Creekmore, KA Walt, JR Schultz-Norton… - Molecular and cellular …, 2008 - Elsevier
The differential recruitment of coregulatory proteins to the DNA-bound estrogen receptor α (ERα)
plays a critical role in mediating estrogen-responsive gene expression. We previously …

3D cell nuclear morphology: microscopy imaging dataset and voxel-based morphometry classification results

…, GA Higgins, G Zheng, A Creekmore… - Proceedings of the …, 2018 - openaccess.thecvf.com
Cell deformation is regulated by complex underlying biological mechanisms associated
with spatial and temporal morphological changes in the nucleus that are related to cell …

Estrogen receptor α regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence

AL Creekmore, YS Ziegler, JL Bonéy… - Molecular and cellular …, 2007 - Elsevier
We have used a chromatin immunoprecipitation (ChIP)-based cloning strategy to isolate and
identify genes associated with estrogen receptor α (ERα) in MCF-7 human breast cancer …

[HTML][HTML] Regulation of cytoskeleton organization by sphingosine in a mouse cell model of progressive ovarian cancer

AL Creekmore, CL Heffron, BP Brayfield, PC Roberts… - Biomolecules, 2013 - mdpi.com
Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer
progression are not well established. We have previously reported the dysregulation of the …

Power frequency magnetic field exposure and gap junctional communication in Clone 9 cells

…, KE Hayden, EJ Miller, VR Dowray, AL Creekmore… - …, 2000 - Elsevier
Exposure to a power-frequency magnetic field has been reported to produce a statistically
significant inhibition of gap junctional communication (GJC) in Clone 9 cells that have been …