[HTML][HTML] Changes in gene expression and cellular architecture in an ovarian cancer progression model
Background Ovarian cancer is the fifth leading cause of cancer deaths among women. Early
stage disease often remains undetected due the lack of symptoms and reliable biomarkers. …
stage disease often remains undetected due the lack of symptoms and reliable biomarkers. …
[HTML][HTML] Chronic stress and intestinal barrier dysfunction: Glucocorticoid receptor and transcription repressor HES1 regulate tight junction protein Claudin-1 promoter
G Zheng, G Victor Fon, W Meixner, A Creekmore… - Scientific reports, 2017 - nature.com
Chronic stress and elevated glucocorticoid hormone are associated with decreases in the
intestinal epithelial tight junction protein claudin-1 (CLDN1). Human/rat CLDN1 promoters …
intestinal epithelial tight junction protein claudin-1 (CLDN1). Human/rat CLDN1 promoters …
Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction
In humans, chronic psychological stress is associated with increased intestinal paracellular
permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent …
permeability and visceral hyperalgesia, which is recapitulated in the chronic intermittent …
[HTML][HTML] 3D shape modeling for cell nuclear morphological analysis and classification
…, JR de Wet, GA Higgins, G Zheng, A Creekmore… - Scientific reports, 2018 - nature.com
Quantitative analysis of morphological changes in a cell nucleus is important for the
understanding of nuclear architecture and its relationship with pathological conditions such as …
understanding of nuclear architecture and its relationship with pathological conditions such as …
Structural and functional alterations in the colonic microbiome of the rat in a model of stress induced irritable bowel syndrome
NH Fourie, D Wang, SK Abey, AL Creekmore… - Gut …, 2017 - Taylor & Francis
Stress is known to perturb the microbiome and exacerbate irritable bowel syndrome (IBS)
associated symptoms. Characterizing structural and functional changes in the microbiome is …
associated symptoms. Characterizing structural and functional changes in the microbiome is …
The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor α mediated gene expression
AL Creekmore, KA Walt, JR Schultz-Norton… - Molecular and cellular …, 2008 - Elsevier
The differential recruitment of coregulatory proteins to the DNA-bound estrogen receptor α (ERα)
plays a critical role in mediating estrogen-responsive gene expression. We previously …
plays a critical role in mediating estrogen-responsive gene expression. We previously …
3D cell nuclear morphology: microscopy imaging dataset and voxel-based morphometry classification results
…, GA Higgins, G Zheng, A Creekmore… - Proceedings of the …, 2018 - openaccess.thecvf.com
Cell deformation is regulated by complex underlying biological mechanisms associated
with spatial and temporal morphological changes in the nucleus that are related to cell …
with spatial and temporal morphological changes in the nucleus that are related to cell …
Estrogen receptor α regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence
AL Creekmore, YS Ziegler, JL Bonéy… - Molecular and cellular …, 2007 - Elsevier
We have used a chromatin immunoprecipitation (ChIP)-based cloning strategy to isolate and
identify genes associated with estrogen receptor α (ERα) in MCF-7 human breast cancer …
identify genes associated with estrogen receptor α (ERα) in MCF-7 human breast cancer …
[HTML][HTML] Regulation of cytoskeleton organization by sphingosine in a mouse cell model of progressive ovarian cancer
AL Creekmore, CL Heffron, BP Brayfield, PC Roberts… - Biomolecules, 2013 - mdpi.com
Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer
progression are not well established. We have previously reported the dysregulation of the …
progression are not well established. We have previously reported the dysregulation of the …
Power frequency magnetic field exposure and gap junctional communication in Clone 9 cells
…, KE Hayden, EJ Miller, VR Dowray, AL Creekmore… - …, 2000 - Elsevier
Exposure to a power-frequency magnetic field has been reported to produce a statistically
significant inhibition of gap junctional communication (GJC) in Clone 9 cells that have been …
significant inhibition of gap junctional communication (GJC) in Clone 9 cells that have been …