A suboptimal early-life environment, due to poor nutrition or stress during pregnancy, can
influence lifelong phenotypes in the progeny. Epigenetic factors are thought to be key …

BACKGROUND Studies in non-human mammals suggest that environmental factors can
influence spermatozoal DNA methylation, and some research suggests that spermatozoal DNA …

Background Ribosomal DNA (rDNA) displays substantial inter-individual genetic variation
in human and mouse. A systematic analysis of how this variation impacts epigenetic states …

The naked mole-rat, Heterocephalus glaber (NMR), the longest-lived rodent, is of significance
and interest in the study of biomarkers for ageing. Recent breakthroughs in this field have …

Background Environmental influences fluctuate throughout the life course of an organism. It
is therefore important to understand how the timing of exposure impacts molecular responses…

… Francisco Rodriguez-Algarra1, Amy F Danson1†, Robert AE Seaborne1†, Selin
Yildizoglu1†, … Danson AF, Marzi SJ, Lowe R, Holland ML, Rakyan VK. Early life diet …

Sub-optimal early life environments can influence life-long phenotypes, and epigenetic factors
are thought to be key mediators of these effects. We show that early life protein restriction …

We present an algorithm and an implementation to insert broadleaves or needleleaves into
a quantitative structure model according to an arbitrary distribution, and a data structure to …

Bacterial enhancer-binding proteins (bEBPs) are specialised transcriptional activators. bEBPs
are hexameric AAA + ATPases and use ATPase activities to remodel RNA polymerase (…

Cellular RNA polymerase is a multi-subunit macromolecular assembly responsible for gene
transcription, a highly regulated process conserved from bacteria to humans. In bacteria, …