[HTML][HTML] Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
EC Larson, AL Ellis-Connell, MA Rodgers… - Nature …, 2023 - nature.com
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette–…
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille Calmette–…
Cellular microRNAs 200b and 429 regulate the Epstein-Barr virus switch between latency and lytic replication
AL Ellis-Connell, T Iempridee, I Xu, JE Mertz - Journal of virology, 2010 - Am Soc Microbiol
We previously showed that the cellular proteins ZEB1 and ZEB2/SIP1 both play key roles in
regulating the latent-lytic switch of Epstein-Barr Virus (EBV) by repressing BZLF1 gene …
regulating the latent-lytic switch of Epstein-Barr Virus (EBV) by repressing BZLF1 gene …
ALT-803 transiently reduces simian immunodeficiency virus replication in the absence of antiretroviral treatment
AL Ellis-Connell, AJ Balgeman, KR Zarbock… - Journal of …, 2018 - Am Soc Microbiol
Developing biological interventions to control human immunodeficiency virus (HIV) replication
in the absence of antiretroviral therapy (ART) could contribute to the development of a …
in the absence of antiretroviral therapy (ART) could contribute to the development of a …
Control of simian immunodeficiency virus infection in prophylactically vaccinated, antiretroviral treatment-naive macaques is required for the most efficacious CD8 T …
AL Ellis-Connell, AJ Balgeman, OE Harwood… - Journal of …, 2022 - Am Soc Microbiol
The IL-15 superagonist N-803 has been shown to enhance the function of CD8 T cells and
NK cells. We previously found that in a subset of vaccinated, ART-naive, SIV + rhesus …
NK cells. We previously found that in a subset of vaccinated, ART-naive, SIV + rhesus …
Preexisting simian immunodeficiency virus infection increases susceptibility to tuberculosis in mauritian cynomolgus macaques
MA Rodgers, C Ameel, AL Ellis-Connell… - Infection and …, 2018 - Am Soc Microbiol
Tuberculosis (TB), caused by Mycobacterium tuberculosis , is the leading cause of death
among human immunodeficiency virus (HIV)-positive patients. The precise mechanisms by …
among human immunodeficiency virus (HIV)-positive patients. The precise mechanisms by …
[HTML][HTML] Vaccination with intravenous BCG protects macaques with pre-existing SIV infection from tuberculosis
EC Larson, AL Ellis-Connell, MA Rodgers… - Research …, 2023 - ncbi.nlm.nih.gov
Tuberculosis (TB) is the most common cause of death in people living with HIV. BCG
delivered intradermally (ID) is the only licensed vaccine to prevent TB. However, it offers little …
delivered intradermally (ID) is the only licensed vaccine to prevent TB. However, it offers little …
Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803
…, AJ Balgeman, AJ Weaver, AL Ellis-Connell… - Journal of …, 2022 - Am Soc Microbiol
Vaccine strategies aimed at eliciting human immunodeficiency virus (HIV)-specific CD8 + T
cells are one major target of interest in HIV functional cure strategies. We hypothesized that …
cells are one major target of interest in HIV functional cure strategies. We hypothesized that …
[HTML][HTML] CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post …
…, AJ Balgeman, AJ Weaver, AL Ellis-Connell… - PLoS …, 2023 - journals.plos.org
Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment
control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-…
control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-…
[HTML][HTML] Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment …
JW Cody, AL Ellis-Connell, SL O'Connor… - PLOS Computational …, 2023 - journals.plos.org
Immunotherapeutic cytokines can activate immune cells against cancers and chronic
infections. N-803 is an IL-15 superagonist that expands CD8 + T cells and increases their …
infections. N-803 is an IL-15 superagonist that expands CD8 + T cells and increases their …
IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV+ Macaques
AL Ellis-Connell, AJ Balgeman, NM Kannal… - Infection and …, 2022 - Am Soc Microbiol
Mucosal associated invariant T (MAIT) cells are innate T cells that recognize bacterial
metabolites and secrete cytokines and cytolytic enzymes to destroy infected target cells. This …
metabolites and secrete cytokines and cytolytic enzymes to destroy infected target cells. This …