Importance Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally
associated with the risk of coronary heart disease (CHD), but randomized trials of several …

Aims The causal role of adiposity for several cardiovascular diseases (CVDs) is unclear.
Our primary aim was to apply the Mendelian randomization design to investigate the …

Background Randomised trials of vitamin D supplementation for cardiovascular disease
and all-cause mortality have generally reported null findings. However, generalisability of …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

While comorbidity between coronary heart disease (CHD) and depression is evident, it is
unclear whether the two diseases have shared underlying mechanisms. We performed a range …

Background: The causal role of alcohol consumption for cardiovascular disease remains
unclear. We used Mendelian randomization (MR) to predict the effect of alcohol consumption …

Background Smoking is a well-established cause of lung cancer and there is strong evidence
that smoking also increases the risk of several other cancers. Alcohol consumption has …

Background Whether a modestly elevated homocysteine level is causally associated with
an increased risk of cardiovascular disease remains unestablished. We conducted a …

… Yi-Qian Sun,1 Stephen Burgess,2,3 James R Staley,3,4 Angela M Wood,3,5 Steven Bell3,5
Stephen K Kaptoge,3,5 Qi Guo,3,5 Thomas R Bolton,3,5 Amy M Mason,3 Adam S …

Aims The aim of this study was to use Mendelian randomization (MR) to determine the
causality of the association between smoking and 14 different cardiovascular diseases (CVDs). …