The cell biology of rabies virus: using stealth to reach the brain

…, JP McGettigan, C Wirblich, A Papaneri - Nature reviews …, 2010 - nature.com
Rabies virus, the prototypical neurotropic virus, causes one of the most lethal zoonotic diseases.
According to official estimates, over 55,000 people die of the disease annually, but this …

A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicity

M Faber, ML Faber, A Papaneri, M Bette… - Journal of …, 2005 - Am Soc Microbiol
Several rabies virus (RV) vaccine strains containing an aspartic acid (Asp) or glutamic acid (Glu)
instead of an arginine (Arg) at position 333 of the RV glycoprotein (G) are apathogenic …

[HTML][HTML] Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine

JE Blaney, A Marzi, M Willet, AB Papaneri… - PLoS …, 2013 - journals.plos.org
We have previously described the generation of a novel Ebola virus (EBOV) vaccine platform
based on (a) replication-competent rabies virus (RABV), (b) replication-deficient RABV, or (…

[PDF][PDF] Spectrally resolved fiber photometry for multi-component analysis of brain circuits

C Meng, J Zhou, A Papaneri, T Peddada, K Xu, G Cui - Neuron, 2018 - cell.com
To achieve simultaneous measurement of multiple cellular events in molecularly defined
groups of neurons in vivo, we designed a spectrometer-based fiber photometry system that …

Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses

JE Blaney, C Wirblich, AB Papaneri… - Journal of …, 2011 - Am Soc Microbiol
The search for a safe and efficacious vaccine for Ebola virus continues, as no current vaccine
candidate is nearing licensure. We have developed (i) replication-competent, (ii) replication…

PPEY motif within the rabies virus (RV) matrix protein is essential for efficient virion release and RV pathogenicity

C Wirblich, GS Tan, A Papaneri, PJ Godlewski… - Journal of …, 2008 - Am Soc Microbiol
Late (L) domains containing the highly conserved sequence PPXY were first described for
retroviruses, and later research confirmed their conservation and importance for efficient …

Preclinical development of inactivated rabies virus–based polyvalent vaccine against rabies and filoviruses

M Willet, D Kurup, A Papaneri, C Wirblich… - The Journal of …, 2015 - academic.oup.com
We previously described the generation of a novel Ebola virus (EBOV) vaccine based on
inactivated rabies virus (RABV) containing EBOV glycoprotein (GP) incorporated in the RABV …

An inactivated Rabies virus–based Ebola Vaccine, FILORAB1, adjuvanted with glucopyranosyl lipid A in stable emulsion confers complete protection in nonhuman …

…, C Fisher, R Keshwara, A Papaneri… - The Journal of …, 2016 - academic.oup.com
The 2013–2016 West African Ebola virus (EBOV) disease outbreak was the largest filovirus
outbreak to date. Over 28 000 suspected, probable, or confirmed cases have been reported, …

Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene

J Cenna, GS Tan, AB Papaneri, B Dietzschold… - Vaccine, 2008 - Elsevier
The type of immune response induced by a vaccine is a critical factor that determines its
effectiveness in preventing infection or disease. Inactivated and live rabies virus (RV) vaccine …

Replication-deficient rabies virus–based vaccines are safe and immunogenic in mice and nonhuman primates

J Cenna, M Hunter, GS Tan, AB Papaneri… - The Journal of …, 2009 - academic.oup.com
Although current postexposure prophylaxis rabies virus (RV) vaccines are effective, ∼40,000–70,000
rabies-related deaths are reported annually worldwide. The development of …