User profiles for Amy Shaub Maddox

Amy S. Maddox

University of North Carolina at Chapel Hill
Verified email at unc.edu
Cited by 2904

RhoA is required for cortical retraction and rigidity during mitotic cell rounding

AS Maddox, K Burridge - The Journal of cell biology, 2003 - rupress.org
Mitotic cell rounding is the process of cell shape change in which a flat interphase cell
becomes spherical at the onset of mitosis. Rearrangement of the actin cytoskeleton, de-adhesion, …

The myriad roles of Anillin during cytokinesis

AJ Piekny, AS Maddox - Seminars in cell & developmental biology, 2010 - Elsevier
Anillin is a highly conserved multidomain protein that interacts with cytoskeletal components
as well as their regulators. Throughout phylogeny, Anillins contribute to cytokinesis, the cell …

[HTML][HTML] Anillin and the septins promote asymmetric ingression of the cytokinetic furrow

AS Maddox, L Lewellyn, A Desai, K Oegema - Developmental cell, 2007 - cell.com
During cytokinesis, constriction of a cortical contractile ring generates a furrow that partitions
one cell into two. The contractile ring contains three filament systems: actin, bipolar myosin …

Distinct roles for two C. elegans anillins in the gonad and early embryo

AS Maddox, B Habermann, A Desai, K Oegema - 2005 - journals.biologists.com
Anillins are conserved proteins that are important for stabilizing and remodeling the actin
cytoskeleton. Anillins have been implicated in cytokinesis in several systems and in …

Cytokinesis, ploidy and aneuploidy

B Lacroix, AS Maddox - The Journal of pathology, 2012 - Wiley Online Library
Cytokinesis is the last step of cell division that physically separates the daughter cells. As
such, it ensures the proper inheritance of both nuclear and cytoplasmic contents. …

Polar body cytokinesis

AS Maddox, J Azoury, J Dumont - Cytoskeleton, 2012 - Wiley Online Library
Amy Shaub MaddoxAmy Shaub Maddox … elegans oocytes results in unstable polar bodies
that fail at variable steps in extrusion [Maddox et al., 2005; Dorn et al., 2010]. Blebbing of the …

Cross-linkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis

…, PS Maddox, F Nedelec, AS Maddox - Molecular Biology of …, 2018 - Am Soc Cell Biol
Cell shape changes such as cytokinesis are driven by the actomyosin contractile cytoskeleton.
The molecular rearrangements that bring about contractility in nonmuscle cells are …

[PDF][PDF] A sterile 20 family kinase and its co-factor CCM-3 regulate contractile ring proteins on germline intercellular bridges

…, A Love, ME Werner, I MacLeod, JR Yates, AS Maddox - Current Biology, 2017 - cell.com
Germ cells in most animals are connected by intercellular bridges, actin-based rings that form
stable cytoplasmic connections between cells promoting communication and coordination […

A theoretical model of cytokinesis implicates feedback between membrane curvature and cytoskeletal organization in asymmetric cytokinetic furrowing

…, B Lacroix, PS Maddox, J Liu, AS Maddox - Molecular biology of …, 2016 - Am Soc Cell Biol
During cytokinesis, the cell undergoes a dramatic shape change as it divides into two
daughter cells. Cell shape changes in cytokinesis are driven by a cortical ring rich in actin …

[PDF][PDF] Anillin

L Zhang, AS Maddox - Current Biology, 2010 - cell.com
What is anillin? Anillin is a conserved protein with a unique multi-domain structure that
implicates it in the crosslinking of multiple structural and regulatory elements. Anillins are …