PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated
protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has …

A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating
kinase (RK) [Lee et al. (1994) Nature 372, 739–746]. We now show that one of these …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of
cellular stresses as well as in response to inflammatory cytokines. There are four members …

Tumour necrosis factor (TNF) is a pleiotropic cytokine, the activities of which include effects
on gene expression, cell growth and cell death. The biological signalling mechanisms which …

Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular
stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of …

The compound BIRB796 inhibits the stress-activated protein kinases p38α and p38β and is
undergoing clinical trials for the treatment of inflammatory diseases. Here we report that …

The paired helical filament, which comprises the major fibrous element of the neurofibrillary
lesions of Alzheimer's disease, is composed of hyperphosphorylated microtubule-associated …

Stress‐activated protein kinase‐3 (SAPK3), a recently described MAP kinase family member
with a widespread tissue distribution, was transfected into several mammalian cell lines …

The differentiation of C2C12 myoblasts to myotubes was found to be accompanied by a
strong activation of p70 S6 kinase and the mitogen-activated protein kinase (MAPK) family …

Activation of the p38 MAP kinase pathways is crucial for the adaptation of mammalian cells
to changes in the osmolarity of the environment. Here we identify SAP97/hDlg, the …