IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization
…, A Dongre, F Reinhardt, A Henderson, AG Del Rio… - Nature cell …, 2018 - nature.com
Lack of insight into mechanisms governing breast cancer metastasis has precluded the
development of curative therapies. Metastasis-initiating cancer cells (MICs) are uniquely …
development of curative therapies. Metastasis-initiating cancer cells (MICs) are uniquely …
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
…, SY Lee, A García-del Río… - Emerging Microbes & …, 2021 - Taylor & Francis
A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia
decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) …
decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) …
[HTML][HTML] Hypoxia promotes syndecan-3 expression in the tumor microenvironment
…, L Egia-Mendikute, A Bosch, A García del Río… - Frontiers in …, 2020 - frontiersin.org
The syndecan (Sdc) family is comprised of four members of cell surface molecules (Sdc-1 to
4) with different biological functions. Syndecan-3 (Sdc-3) is known to be mainly expressed …
4) with different biological functions. Syndecan-3 (Sdc-3) is known to be mainly expressed …
[HTML][HTML] Factor-inhibiting HIF (FIH) promotes lung cancer progression
A García-del Río, E Prieto-Fernández… - JCI insight, 2023 - ncbi.nlm.nih.gov
Factor-inhibiting HIF (FIH) is an asparagine hydroxylase that acts on hypoxia-inducible factors
(HIFs) to control cellular adaptation to hypoxia. FIH is expressed in several tumor types, …
(HIFs) to control cellular adaptation to hypoxia. FIH is expressed in several tumor types, …
[HTML][HTML] SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer
…, LE Zapata-Pavas, A García-del Río… - Cell reports, 2024 - cell.com
The posttranslational modification of proteins critically influences many biological processes
and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R …
and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R …
[HTML][HTML] A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants
…, B Jiménez-Lasheras, A García del Río… - Frontiers in …, 2022 - frontiersin.org
Vaccines against SARS-CoV-2 have alleviated infection rates, hospitalization and deaths
associated with COVID-19. In order to monitor humoral immunity, several serology tests have …
associated with COVID-19. In order to monitor humoral immunity, several serology tests have …
[HTML][HTML] Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals
…, SY Lee, B Jiménez-Lasheras, A Garcia del Rio… - Communications …, 2021 - nature.com
There is an ongoing need of developing sensitive and specific methods for the determination
of SARS-CoV-2 seroconversion. For this purpose, we have developed a multiplexed flow …
of SARS-CoV-2 seroconversion. For this purpose, we have developed a multiplexed flow …
The Mitochondrial Isoform of FASTK Modulates Nonopsonic Phagocytosis of Bacteria by Macrophages via Regulation of Respiratory Complex I
Phagocytosis is a pivotal process by which innate immune cells eliminate bacteria. In this
study, we explore novel regulatory mechanisms of phagocytosis driven by the mitochondria. …
study, we explore novel regulatory mechanisms of phagocytosis driven by the mitochondria. …
Implicación metodológica de las herramientas 2.0 para el aprendizaje colaborativo del alumnado
…, M Simarro Grande, A García del Río - 2016 - uvadoc.uva.es
El proyecto se ha dirigido a estudiantes de Grado de 1º,2º y 3º curso de la Facultad de
Enfermería de la Universidad de Valladolid en las asignaturas de Nutrición Humana, Dietética y …
Enfermería de la Universidad de Valladolid en las asignaturas de Nutrición Humana, Dietética y …
Papel de la isoforma mitocondrial de FASTK en la modulación de la fagocitosis no opsónica de bacterias por los macrófagos
A García del Río - 2019 - uvadoc.uva.es
La mitocondria es un orgánulo esencial para la función celular, incluyendo la generación
celular de la energía en forma de ATP a través de la fosforilación oxidativa (OXPHOS) y la …
celular de la energía en forma de ATP a través de la fosforilación oxidativa (OXPHOS) y la …