For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …

The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) …

Significance: Enhanced levels of reactive oxygen species (ROS) have been associated with
different disease states. Most attempts to validate and exploit these associations by chronic …

Transgenic sorghum plants have been obtained after microprojectile bombardment of
immature zygotic embryos of a drought-resistant sorghum cultivar, P898012. DNA delivery …

Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based
rather than mechanistic approaches have contributed. We here explore a mechanism…

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

Ischemic injury represents the most frequent cause of death and disability, and it remains
unclear why, of all body organs, the brain is most sensitive to hypoxia. In many tissues, type 4 …

Traditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs
provides an alternative with lower costs and faster drug development timelines. However, the …

Background According to the “World Cancer Research Fund” and the “American Institute of
Cancer Research” (WCRF/AICR) one in four cancer cases could be prevented through a …

Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an
adjuvant/monotherapy for the management of depression. A recent study by our group …