The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving
entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence variability
1 . Many studies suggest that mtDNA variants may be associated with ageing or diseases 2 …

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely unexplored…

Electron flux in the mitochondrial electron transport chain is determined by the superassembly
of mitochondrial respiratory complexes. Different superassemblies are dedicated to …

mtDNA is present in multiple copies in each cell derived from the expansions of those in the
oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, …

Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems
during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described and …

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may
be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck …

Characteristic or classic phenotype of Cornelia de Lange syndrome (CdLS) is associated
with a recognisable facial pattern. However, the heterogeneity in causal genes and the …

Post-translational modifications hugely increase the functional diversity of proteomes.
Recent algorithms based on ultratolerant database searching are forging a path to unbiased …

Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to
different environmental stressors. We used a whole-body and tissue-specific phenotypic, …