Propionibacterium freudenreichii CIRM-BIA 129 (P. freudenreichii wild type, WT) is a probiotic
bacterium, which exerts immunomodulatory effects. This strain possesses extractable …

Background Many probiotic bacteria have been described as promising tools for the treatment
and prevention of inflammatory bowel diseases (IBDs). Most of these bacteria are lactic …

Hypertension is a major global health challenge, as it represents the main risk factor for
stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high …

Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is
known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of …

Excess intake of sodium is often associated with high risk for cardiovascular disease. More
recently, some studies on the effects of high-salt diets (HSDs) have also demonstrated that …

Abstract Changes in blood epigenetic age have been associated with several pathological
conditions and have recently been described to anticipate cancer development. In this work, …

IL-10 is a regulatory cytokine that plays a major role in the homeostasis of the gut and this is
illustrated by the fact that IL-10 −/− mice develop spontaneous colitis. In this study, IL-10 −/− …

The intestinal mucosa is the major site of contact with antigens, and it houses the largest
lymphoid tissue in the body. In physiological conditions, microbiota and dietary antigens are the …

Alterations in the composition of the intestinal microbiota have been associated with
development of type 1 diabetes (T1D), but little is known about changes in intestinal homeostasis …

The conceptualization of immunological self is amongst the most important theories of modern
biology, representing a sort of theoretical guideline for experimental immunologists, in …